Wine, fibrinolysis and health

Consuelo Pasten, Hernán E. Grenett

Resultado de la investigación: Contribución a una revistaReseña científicarevisión exhaustiva

2 Citas (Scopus)

Resumen

Cardiovascular diseases are the leading cause of death in both men and women in the world. Epidemiological and experimental studies have associated moderate wine consumption (1 to 2 glasses/day) with a decrease in cardiovascular diseases. This decrease is probably due to the effect of ethanol and polyphenols present in the wine. The cardioprotective benefit of wine may be due, in part, to a modulation of the expression of proteins involved in fibrinolysis. Endothelial cells (ECs) play a major role in maintaining normal hemostasis, regulating the balance between the synthesis and interaction of proteins that promote clot formation (thrombosis) and fibrinolytic proteins that facilitate clot lysis. These cells are a major site of synthesis of fibrinolytic proteins, such as tissue type plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA) and the major inhibitor/regulator of fibrinolysis, PAI-1. EC-mediated fibrinolysis is regulated and localized to the EC surface through specific receptors for u-PA, t-PA and plasminogen. Evidence indicates that ethanol and polyphenols present in wine increase EC localized fibrinolisis. Upregulation of t-PA and u-PA activity and downregulation of PAI-1 may account, at least in part, for this net increase in fibrinolytic activity. The purpose of this review is to cover the main molecular and physiological aspects of moderate wine consumption mediated increase in fibrinolysis and reduction in cardiovascular risk.
Idioma originalInglés estadounidense
Páginas (desde-hasta)1040-1048
Número de páginas9
PublicaciónRevista Medica de Chile
Volumen134
N.º8
EstadoPublicada - 28 nov 2006
Publicado de forma externa

Palabras clave

  • Cardiovascular diseases
  • Fibrinolysis
  • Thrombosis
  • Wine

Huella Profundice en los temas de investigación de 'Wine, fibrinolysis and health'. En conjunto forman una huella única.

Citar esto