Salud ósea en pacientes sometidos a trasplante de precursors hematopoyéticos: Un nuevo problema a considerar

V. Pablo Florenzano*, Daniel Ernst, Nicole Lustig, Patricio Rojas, Pablo Ramírez, Claudia Campusano

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)

Resumen

Background: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. Aim: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. Patients and Methods: Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT. Results: Ninety patients were included, 53 were evaluated prior to HCT and 37 after HCT. They represent 73% of all patients undergoing HCT in the period. Median 25OHD was 12 ng/ml (range 4-41.4). Ninety seven percent of patients had levels considered insufficient and 85% compatible with deficiency. Median PTH was 60.5 pg/ml (range 21-186). Forty five percent of patients had secondary hyperparathyroidism. DXA was performed in 65 patients (prior to HCT in 54 and after HCT in 11). Of these, 11% had had a low bone mineral density. Conclusions: Patients undergoing HCT have a high risk of vitamin D deficiency, secondary hyperparathyroidism and low bone mineral density.

Título traducido de la contribuciónVitamin D and parathyroid hormone levels and bone mineral density in patients undergoing hematopoietic cell transplantation
Idioma originalEspañol
Páginas (desde-hasta)1119-1124
Número de páginas6
PublicaciónRevista Medica de Chile
Volumen144
N.º9
DOI
EstadoPublicada - sept. 2016
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2016, Sociedad Medica de Santiago. All rights reserved.

Palabras clave

  • Hematopoietic stem cell transplantation
  • Hyperparathyroidism secondary
  • Osteoporosis
  • Vitamin D

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