Tuning a P450 enzyme for methane oxidation

Felipe E. Zilly; Juan P. Acevedo; Wojciech Augustyniak; Alfred Deege; Manfred T. Reetz

doi:10.1002/anie.201006587

Tuning a P450 enzyme for methane oxidation

Felipe E. Zilly, Juan P. Acevedo, Wojciech Augustyniak, Alfred Deege, Manfred T. Reetz

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

129 Citas (Scopus)

Resumen

A new spin: The addition of chemically inert perfluoro carboxylic acids (green; see picture) to P450 enzymes results in dramatic activation of their catalytic activity as a result of the conversion of the Fe/heme from a low-spin to a high-spin state, and the reduction of the binding-pocket size. Together these effects allow otherwise inert substrates such as propane and even methane to be oxidized.

Idioma original	Inglés
Páginas (desde-hasta)	2720-2724
Número de páginas	5
Publicación	Angewandte Chemie - International Edition
Volumen	50
N.º	12
DOI	https://doi.org/10.1002/anie.201006587
Estado	Publicada - 14 mar. 2011
Publicado de forma externa	Sí

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title = "Tuning a P450 enzyme for methane oxidation",

abstract = "A new spin: The addition of chemically inert perfluoro carboxylic acids (green; see picture) to P450 enzymes results in dramatic activation of their catalytic activity as a result of the conversion of the Fe/heme from a low-spin to a high-spin state, and the reduction of the binding-pocket size. Together these effects allow otherwise inert substrates such as propane and even methane to be oxidized.",

keywords = "C-H activation, P450 enzymes, alkanes, host-guest systems, methane oxidation",

author = "Zilly, {Felipe E.} and Acevedo, {Juan P.} and Wojciech Augustyniak and Alfred Deege and Reetz, {Manfred T.}",

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AU - Acevedo, Juan P.

AU - Augustyniak, Wojciech

AU - Deege, Alfred

AU - Reetz, Manfred T.

PY - 2011/3/14

Y1 - 2011/3/14

N2 - A new spin: The addition of chemically inert perfluoro carboxylic acids (green; see picture) to P450 enzymes results in dramatic activation of their catalytic activity as a result of the conversion of the Fe/heme from a low-spin to a high-spin state, and the reduction of the binding-pocket size. Together these effects allow otherwise inert substrates such as propane and even methane to be oxidized.

AB - A new spin: The addition of chemically inert perfluoro carboxylic acids (green; see picture) to P450 enzymes results in dramatic activation of their catalytic activity as a result of the conversion of the Fe/heme from a low-spin to a high-spin state, and the reduction of the binding-pocket size. Together these effects allow otherwise inert substrates such as propane and even methane to be oxidized.

KW - C-H activation

KW - P450 enzymes

KW - alkanes

KW - host-guest systems

KW - methane oxidation

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JO - Angewandte Chemie - International Edition

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Tuning a P450 enzyme for methane oxidation

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