Tumores Neuroendocrinos: Un desafío transversal

Diego Carrillo; Matías Muñoz Medel; Ignacio Retamal; Mauricio Pinto; María L. Bravo; Bruno Nervi; José Peña; Yasna Valenzuela; Francisco J. Guarda; Flavia Nilo; Fernando Bello; Pilar Orellana; Daniel Vicentini; Juan Carlos Quintana; Paula J.  Torres; José Luis Leal; Marcelo Garrido

doi:10.4067/S0034-98872021000600888

Tumores Neuroendocrinos: Un desafío transversal

Diego Carrillo
, Matías Muñoz Medel
, Ignacio Retamal
, Mauricio Pinto
, María L. Bravo
, Bruno Nervi
, José Peña
, Yasna Valenzuela
, Francisco J. Guarda
, Flavia Nilo
, Fernando Bello
, Pilar Orellana
, Daniel Vicentini
, Juan Carlos Quintana
, Paula J. Torres
, José Luis Leal
, Marcelo Garrido^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

6 Citas (Scopus)

Resumen

Los tumores neuroendocrinos (TNEs) constituyen un grupo heterogéneo de neoplasias que se originan a partir de células neuroendocrinas, productoras de monoaminas, péptidos y otras sustancias biológicamente activas, ampliamente distribuidas en el organismo. El estudio de los TNEs tiene más de un siglo de historia. En 1888, Lubarsch fue uno de los pioneros al describir múltiples tumores en el íleon en una autopsia1; poco después, en 1907, Oberndorfer acuñó el término karzinoid para describir un grupo de tumores con un comportamiento menos agresivo comparado con los adenocarcinomas2. En la década de 1950 surgieron los primeros reportes de manifestaciones clínicas características asociadas a tumores carcinoides, lo que posteriormente se denominó síndrome carcinoide (SC).

Título traducido de la contribución	Update on neuroendocrine tumors
Idioma original	Español
Páginas (desde-hasta)	888-898
Número de páginas	11
Publicación	Revista Medica de Chile
Volumen	149
N.º	6
DOI	https://doi.org/10.4067/S0034-98872021000600888
Estado	Publicada - jun. 2021
Publicado de forma externa	Sí

Nota bibliográfica

Publisher Copyright:
© 2021 Sociedad Medica de Santiago. All rights reserved.

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

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10.4067/S0034-98872021000600888Licencia: CC BY

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Carrillo, D., Muñoz Medel, M., Retamal, I., Pinto, M., Bravo, M. L., Nervi, B., Peña, J., Valenzuela, Y., Guarda, F. J., Nilo, F., Bello, F., Orellana, P., Vicentini, D., Quintana, J. C., Torres, P. J., Leal, J. L., & Garrido, M. (2021). Tumores Neuroendocrinos: Un desafío transversal. Revista Medica de Chile, 149(6), 888-898. https://doi.org/10.4067/S0034-98872021000600888

@article{f4e05b63fa314afead8e07f8f1f01d12,

title = "Tumores Neuroendocrinos: Un desaf{\'i}o transversal",

abstract = "Neuroendocrine Tumors (NETs) encompass a wide variety of tumors arising from neuroendocrine cells, which produce bioactive substances. The incidence of NETs increased significantly lately, becoming one of the most common tumors of the digestive tract. Their clinical presentation is as diverse as their capacity for hormone production. Carcinoid syndrome is the most common hormonal syndrome produced by NETs and is characterized by diarrhea, flushing and cardiac valvular lesions. New research brought multiple changes in the classification of these neoplasms and a new understanding about their diagnosis and treatment, promoting a multidisciplinary approach. Somatostatin analogues, radiation, biological, and cytotoxic drugs have improved the prognosis of these patients, which entails a great challenge for healthcare providers.",

keywords = "Biomarkers, Tumor, Malignant Carcinoid Syndrome, Neuroendocrine Tumors, Somatostatin",

author = "Diego Carrillo and \{Mu{\~n}oz Medel\}, Mat{\'i}as and Ignacio Retamal and Mauricio Pinto and Bravo, \{Mar{\'i}a L.\} and Bruno Nervi and Jos{\'e} Pe{\~n}a and Yasna Valenzuela and Guarda, \{Francisco J.\} and Flavia Nilo and Fernando Bello and Pilar Orellana and Daniel Vicentini and Quintana, \{Juan Carlos\} and Torres, \{Paula J.\} and Leal, \{Jos{\'e} Luis\} and Marcelo Garrido",

year = "2021",

month = jun,

doi = "10.4067/S0034-98872021000600888",

language = "Spanish",

volume = "149",

pages = "888--898",

journal = "Revista Medica de Chile",

issn = "0034-9887",

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T2 - Un desafío transversal

AU - Carrillo, Diego

AU - Muñoz Medel, Matías

AU - Retamal, Ignacio

AU - Pinto, Mauricio

AU - Bravo, María L.

AU - Nervi, Bruno

AU - Peña, José

AU - Valenzuela, Yasna

AU - Guarda, Francisco J.

AU - Nilo, Flavia

AU - Bello, Fernando

AU - Orellana, Pilar

AU - Vicentini, Daniel

AU - Quintana, Juan Carlos

AU - Torres, Paula J.

AU - Leal, José Luis

AU - Garrido, Marcelo

PY - 2021/6

Y1 - 2021/6

N2 - Neuroendocrine Tumors (NETs) encompass a wide variety of tumors arising from neuroendocrine cells, which produce bioactive substances. The incidence of NETs increased significantly lately, becoming one of the most common tumors of the digestive tract. Their clinical presentation is as diverse as their capacity for hormone production. Carcinoid syndrome is the most common hormonal syndrome produced by NETs and is characterized by diarrhea, flushing and cardiac valvular lesions. New research brought multiple changes in the classification of these neoplasms and a new understanding about their diagnosis and treatment, promoting a multidisciplinary approach. Somatostatin analogues, radiation, biological, and cytotoxic drugs have improved the prognosis of these patients, which entails a great challenge for healthcare providers.

AB - Neuroendocrine Tumors (NETs) encompass a wide variety of tumors arising from neuroendocrine cells, which produce bioactive substances. The incidence of NETs increased significantly lately, becoming one of the most common tumors of the digestive tract. Their clinical presentation is as diverse as their capacity for hormone production. Carcinoid syndrome is the most common hormonal syndrome produced by NETs and is characterized by diarrhea, flushing and cardiac valvular lesions. New research brought multiple changes in the classification of these neoplasms and a new understanding about their diagnosis and treatment, promoting a multidisciplinary approach. Somatostatin analogues, radiation, biological, and cytotoxic drugs have improved the prognosis of these patients, which entails a great challenge for healthcare providers.

KW - Biomarkers

KW - Tumor

KW - Malignant Carcinoid Syndrome

KW - Neuroendocrine Tumors

KW - Somatostatin

UR - https://www.scopus.com/pages/publications/85119580216

U2 - 10.4067/S0034-98872021000600888

DO - 10.4067/S0034-98872021000600888

M3 - Review article

C2 - 34751348

AN - SCOPUS:85119580216

SN - 0034-9887

VL - 149

SP - 888

EP - 898

JO - Revista Medica de Chile

JF - Revista Medica de Chile

IS - 6

ER -

Tumores Neuroendocrinos: Un desafío transversal

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