Transplantation of fecal matter in octogenarian patients with recurrent clostridioides difficile infection

Rodrigo Quera*, Rocío Sedano, Ricardo Espinoza, Daniela Rivera

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Clostridioides (formerly Clostridium) difficile infection has become a major health problem due to the increase in its incidence, severity, and recurrence. In this last scenario, age over 65 has been associated with a more unfavorable evolution. Risk factors such as the presence of altered immunity, comorbidities, malnutrition, polypharmacy, and changes in the intestinal microbiota would explain this higher risk in this group of patients. On the other hand, fecal microbiota transplantation (FMT) is an effective strategy in the treatment of recurrent Clostridioides difficile infection when standard therapy fails. Recently published guidelines suggest that this strategy can be used from the second recurrence. However, few studies have evaluated the results of the FMT in patients over 65 years old, and for our knowledge, there is limited national experience in this group of patients. We present two cases of TMF in octogenarian patients with a recurrent infection due to Clostridioides difficile, with satisfactory recovery at the long term. © 2019, Sociedad Chilena de Infectologia. All rights reserved.
Título traducido de la contribuciónTransplantation of fecal matter in octogenarian patients with recurrent clostridioides difficile infection
Idioma originalEspañol
Páginas (desde-hasta)536-540
Número de páginas5
PublicaciónRevista Chilena de Infectologia
Volumen36
N.º4
DOI
EstadoPublicada - ago 2019

Nota bibliográfica

Publisher Copyright:
© 2019, Sociedad Chilena de Infectologia. All rights reserved.

Palabras clave

  • Clostridioides difficile
  • Clostridium difficile
  • Comorbidity
  • Elderly
  • Fecal microbiota transplantation

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