TY - JOUR
T1 - The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction
AU - Monteiro, Lara
AU - Peñailillo, Reyna
AU - Sánchez, Mario
AU - Acuña-Gallardo, Stephanie
AU - Mönckeberg, Max
AU - Ong, Judith
AU - Choolani, Mahesh
AU - Illanes, Sebastián
AU - Nardocci, Gino
N1 - Funding Information:
This research was funded by ANID/CONICYT?FONDECYT de Iniciaci?n 11190998 (to G.N.); ANID/CONICYT?FONDECYT de Iniciaci?n 11181249 (to L.J.M.); ANID/CONICYT? FONDECYT Regular 1201851 (to S.E.I.); ANID/CONICYT?FONDECYT Postdoctorado 3160622 (to M.S.).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.
AB - Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.
KW - Intrauterine growth restriction
KW - Long non-coding RNAs
KW - Preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=85109195129&partnerID=8YFLogxK
U2 - 10.3390/genes12070970
DO - 10.3390/genes12070970
M3 - Article
C2 - 34201957
AN - SCOPUS:85109195129
SN - 2073-4425
VL - 12
JO - Genes
JF - Genes
IS - 7
M1 - 970
ER -