TY - JOUR
T1 - The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy
AU - Khoury, Maroun
AU - Alcayaga-Miranda, Francisca
AU - Illanes, Sebastián E.
AU - Figueroa, Fernando E.
N1 - Funding Information:
A part of the experimental work mentioned was funded by the Chilean National Commission for Scientific and Technological Investigation (CONICYT), FONDEF IDeA Program, grant number CA12i10349.
Publisher Copyright:
© 2014 Khoury, Alcayaga-Miranda, Illanes and Figueroa.
PY - 2014
Y1 - 2014
N2 - Menstrual-derived stem cells (MenSCs) are a new source of mesenchymal stem cells isolated from the menstrual fluid. Currently, there is a growing interest in their clinical potential due to fact that they are multipotent, highly proliferative, and easy to obtain in a non-invasive manner. Sampling can be repeated periodically in a simplified and reproducible manner devoid of complications that no existing cell source can match. MenSCs are also free of ethical dilemmas, and display novel properties with regard to presently known adult derived stem cells. This review details their distinctive biological properties regarding immunophenotype and function, proliferation rate, differentiation potential, and paracrine effects mediated by secreted factors. Their possible role in antenatal diagnosis is also discussed. While more insight on their immunomodulatory and diagnostic properties is needed, the impact of clinical and epidemiological factors, such as age, use of contraceptives, or hormonal status still requires further investigations to properly assess their current and future use in clinical application and diagnosis.
AB - Menstrual-derived stem cells (MenSCs) are a new source of mesenchymal stem cells isolated from the menstrual fluid. Currently, there is a growing interest in their clinical potential due to fact that they are multipotent, highly proliferative, and easy to obtain in a non-invasive manner. Sampling can be repeated periodically in a simplified and reproducible manner devoid of complications that no existing cell source can match. MenSCs are also free of ethical dilemmas, and display novel properties with regard to presently known adult derived stem cells. This review details their distinctive biological properties regarding immunophenotype and function, proliferation rate, differentiation potential, and paracrine effects mediated by secreted factors. Their possible role in antenatal diagnosis is also discussed. While more insight on their immunomodulatory and diagnostic properties is needed, the impact of clinical and epidemiological factors, such as age, use of contraceptives, or hormonal status still requires further investigations to properly assess their current and future use in clinical application and diagnosis.
KW - Cell therapy
KW - Menstrual blood
KW - Menstrual stem cells
KW - Mesenchymal stem cells
KW - Stem cells
KW - Cell therapy
KW - Menstrual blood
KW - Mesenchymal stem cells
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84987818356&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2014.00205
DO - 10.3389/fimmu.2014.00205
M3 - Review article
AN - SCOPUS:84987818356
SN - 1664-3224
VL - 5
JO - Frontiers in Immunology
JF - Frontiers in Immunology
IS - MAY
M1 - 205
ER -