Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.
Nota bibliográficaFunding Information:
This work was supported by grants from the Chilean National Commission for Scientific and Technological Investigation-CONICYT for National Agency of Investigation and Develop ANID: “Fondecyt Iniciación” N°11190690; “Fondecyt Regular” N°1211353 “Programa de apoyo a la formación de redes internacionales” N°180211; “Programa de Cooperación Cientı́fica ECOS-CONICYT” N°PC18S04-ECOS180032 and “Beca Doctorado Nacional” 2019 NL-C N° 2191997. We also acknowledge the Agence Nationale pour la Recherche (ANR) for the financial support with the project “PPAROA” (ANR-18-CE18-0010-02), Inserm and the University of Montpellier.
© Copyright © 2021 Luque-Campos, Bustamante-Barrientos, Pradenas, García, Araya, Bohaud, Contreras-López, Elizondo-Vega, Djouad, Luz-Crawford and Vega-Letter.