The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Noymar Luque-Campos, Felipe A. Bustamante-Barrientos, Carolina Pradenas, Cynthia García, María Jesús Araya, Candice Bohaud, Rafael Contreras-López, Roberto Elizondo-Vega, Farida Djouad, Patricia Alejandra Luz Crawford, Ana María Vega-Letter

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Resumen

Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

Idioma originalInglés
Número de artículo624746
PublicaciónFrontiers in Immunology
Volumen12
DOI
EstadoPublicada - 4 jun 2021

Nota bibliográfica

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© Copyright © 2021 Luque-Campos, Bustamante-Barrientos, Pradenas, García, Araya, Bohaud, Contreras-López, Elizondo-Vega, Djouad, Luz-Crawford and Vega-Letter.

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