The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse

Rudolf C. Kuppers*, Leonardo D. Epstein, Ingrid M. Outschoorn, Noel R. Rose

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)

Resumen

The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not Ighj (CBA) allotype.

Idioma originalInglés
Páginas (desde-hasta)404-411
Número de páginas8
PublicaciónImmunogenetics
Volumen39
N.º6
DOI
EstadoPublicada - abr 1994
Publicado de forma externa

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