The axonal endoplasmic reticulum: One organelle—many functions in development, maintenance, and plasticity

Alejandro Luarte, Víctor Hugo Cornejo, Francisca Bertin, Javiera Gallardo, Andrés Couve*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

43 Citas (Scopus)

Resumen

The endoplasmic reticulum (ER) is highly conserved in eukaryotes and neurons. Indeed, the localization of the organelle in axons has been known for nearly half a century. However, the relevance of the axonal ER is only beginning to emerge. In this review, we discuss the structure of the ER in axons, examining the role of ER-shaping proteins and highlighting reticulons. We analyze the multiple functions of the ER and their potential contribution to axonal physiology. First, we examine the emerging roles of the axonal ER in lipid synthesis, protein translation, processing, quality control, and secretory trafficking of transmembrane proteins. We also review the impact of the ER on calcium dynamics, focusing on intracellular mechanisms and functions. We describe the interactions between the ER and endosomes, mitochondria, and synaptic vesicles. Finally, we analyze available proteomic data of axonal preparations to reveal the dynamic functionality of the ER in axons during development. We suggest that the dynamic proteome and a validated axonal interactome, together with state-of-the-art methodologies, may provide interesting research avenues in axon physiology that may extend to pathology and regeneration.

Idioma originalInglés
Páginas (desde-hasta)181-208
Número de páginas28
PublicaciónDevelopmental Neurobiology
Volumen78
N.º3
DOI
EstadoPublicada - mar. 2018
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Huella

Profundice en los temas de investigación de 'The axonal endoplasmic reticulum: One organelle—many functions in development, maintenance, and plasticity'. En conjunto forman una huella única.

Citar esto