TY - JOUR
T1 - Sistemas de nanopartículas poliméricas ii
T2 - Estructura, métodos de elaboración, características, propiedades, biofuncionalización y tecnologías de auto-ensamblaje capa por capa (layer-by-layer self-assembly)
AU - Urrejola, Madelein C.
AU - Soto, Liliam V.
AU - Zumarán, Consuelo C.
AU - Peñaloza, Juan Pablo
AU - Álvarez, Beatriz
AU - Fuentevilla, Ignacio
AU - Haidar, Ziyad S.
N1 - Funding Information:
Este trabajo fue apoyado por las subvenciones de funcionamiento otorgadas al BioMAT'X (La-boratorio de Biomateriales, Farmacéuticos y Bioingeniería de Tejidos Cráneo Máxilo-Facial), miembro del CIIB (Centro de Investigación e Innovación Biomédica), a través de la Facultad de Odontología y Fondo de Ayuda a la Investigación (FAI No. INV-IN-2015-101 2015-2019), Dirección de Investigación, Universidad de los Andes, Santiago de Chile y CONICYT-FONDEF (Grant ID # 16I10366).
Publisher Copyright:
© 2019, Universidad de la Frontera. All rights reserved.
PY - 2018/12
Y1 - 2018/12
N2 - SUMMARY: Polymeric materials have been extensively investigated for biomedical applications including micro-and nanoparticles. Modern advances have broadened horizons for application with peptides and nucleic acids. Therefore, interests increased in the formulation of materials, devices and vehicles for transporting therapeutic agents in functionalized nanostructures. Recent nano-systems are inspired by natural phenomena that stimulate the integration of molecular signals and the mimicking of natural cellular processes, at tissue and organ levels. Technologically, the ability to obtain spherical nanostructures, which combine different properties, that no other single material possesses on its own, makes nanocapsules particularly attractive. Potential advantages over polymer nanoparticulate systems are highlighted throughout each part of this review article. Here, we address the most relevant aspects of structure, composition and methods of formulation of nanoparticulate systems. In addition, we outline some of the more recent works focusing on nanosized preparations, based on agent-directed polymers, found in specialized research articles that have emerged in the recent years.
AB - SUMMARY: Polymeric materials have been extensively investigated for biomedical applications including micro-and nanoparticles. Modern advances have broadened horizons for application with peptides and nucleic acids. Therefore, interests increased in the formulation of materials, devices and vehicles for transporting therapeutic agents in functionalized nanostructures. Recent nano-systems are inspired by natural phenomena that stimulate the integration of molecular signals and the mimicking of natural cellular processes, at tissue and organ levels. Technologically, the ability to obtain spherical nanostructures, which combine different properties, that no other single material possesses on its own, makes nanocapsules particularly attractive. Potential advantages over polymer nanoparticulate systems are highlighted throughout each part of this review article. Here, we address the most relevant aspects of structure, composition and methods of formulation of nanoparticulate systems. In addition, we outline some of the more recent works focusing on nanosized preparations, based on agent-directed polymers, found in specialized research articles that have emerged in the recent years.
KW - Dendrimers
KW - Nanocapsules
KW - Nanospheres
KW - Nanostructures
KW - Quantum dots
UR - http://www.scopus.com/inward/record.url?scp=85059314119&partnerID=8YFLogxK
U2 - 10.4067/S0717-95022018000401463
DO - 10.4067/S0717-95022018000401463
M3 - Article
AN - SCOPUS:85059314119
SN - 0717-9367
VL - 36
SP - 1463
EP - 1471
JO - International Journal of Morphology
JF - International Journal of Morphology
IS - 4
ER -