TY - JOUR
T1 - Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide
AU - Nardocci, Gino
AU - Martin, Aldo
AU - Abarzúa, Sebastián
AU - Rodríguez, Jorge
AU - Simon, Felipe
AU - Reyes, Edison P.
AU - Acuña-Castillo, Claudio
AU - Navarro, Cristina
AU - Cortes, Paula P.
AU - Fernández, Ricardo
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.
AB - Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.
KW - Bilateral carotid/sinus neurotomy
KW - Carotid body
KW - Epinephrine
KW - Glucocorticoids
KW - Multiple organ dysfunction
KW - Sepsis
KW - TNF-α
KW - Tissue damage
UR - http://www.scopus.com/inward/record.url?scp=84920913922&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2014.12.002
DO - 10.1016/j.jneuroim.2014.12.002
M3 - Article
C2 - 25595251
AN - SCOPUS:84920913922
SN - 0165-5728
VL - 278
SP - 44
EP - 52
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -