Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy

Wilfredo Alejandro González-Arriagada; Lara Maria Alencar Ramos; Andreia Aparecida Silva; Pablo Agustin Vargas; Ricardo Della Coletta; Lynne Bingle; Marcio Ajudarte Lopes

doi:10.1016/j.oooo.2014.09.026

Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy

Wilfredo Alejandro González-Arriagada, Lara Maria Alencar Ramos, Andreia Aparecida Silva, Pablo Agustin Vargas, Ricardo Della Coletta, Lynne Bingle, Marcio Ajudarte Lopes^*

^*Autor correspondiente de este trabajo

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9 Citas (Scopus)

Resumen

Materials and Methods Unstimulated whole-mouth saliva was collected from 45 cancer patients (1 week before treatment, during the treatment, and 1 week after completion of radiotherapy) and from 20 controls. BPIFA1 and BPIFA2 expression was detected by western blotting and analyzed along with clinicopathologic data and side effects from the radiotherapy.

Results A facial radiation field was associated with lower salivary flow during and after radiotherapy and correlated with side effects, mainly mucositis. Salivary BPIFA1 expression levels were similar between the control group and the patient group before treatment. On the other hand, BPIFA2 levels were higher in the patient group before treatment compared with the control group. BPIFA concentration was modified by radiotherapy as BPIFA1 levels increased (P =.0081) and BPIFA2 decreased (P <.0001). Higher levels of BPIFA1 were associated with the presence of mucositis (P =.0363) and its severity (P =.0500).

Conclusions The present study found that levels of BPIFA1 and glycosylated forms of BPIFA2 are affected by radiotherapy, suggesting that these proteins may play a role in the oral microenvironment in irradiated patients with head and neck cancer.

Objective To determine the effects of radiotherapy on salivary BPIFA expression and to investigate the role of BPIFA in the development of known radiotherapy side effects.

Idioma original	Inglés
Páginas (desde-hasta)	48-58
Número de páginas	11
Publicación	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volumen	119
N.º	1
DOI	https://doi.org/10.1016/j.oooo.2014.09.026
Estado	Publicada - 1 ene. 2015
Publicado de forma externa	Sí

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Funding Information:
Support for this paper was provided by the National Council for Scientific and Technological Development , (CNPq), Brasilia-DF, Brazil (grants 301668/2010-8 ).

Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.

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@article{4759e93d6b33437b8352de72daa6c101,

title = "Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy",

abstract = "Materials and Methods Unstimulated whole-mouth saliva was collected from 45 cancer patients (1 week before treatment, during the treatment, and 1 week after completion of radiotherapy) and from 20 controls. BPIFA1 and BPIFA2 expression was detected by western blotting and analyzed along with clinicopathologic data and side effects from the radiotherapy.Results A facial radiation field was associated with lower salivary flow during and after radiotherapy and correlated with side effects, mainly mucositis. Salivary BPIFA1 expression levels were similar between the control group and the patient group before treatment. On the other hand, BPIFA2 levels were higher in the patient group before treatment compared with the control group. BPIFA concentration was modified by radiotherapy as BPIFA1 levels increased (P =.0081) and BPIFA2 decreased (P <.0001). Higher levels of BPIFA1 were associated with the presence of mucositis (P =.0363) and its severity (P =.0500).Conclusions The present study found that levels of BPIFA1 and glycosylated forms of BPIFA2 are affected by radiotherapy, suggesting that these proteins may play a role in the oral microenvironment in irradiated patients with head and neck cancer.Objective To determine the effects of radiotherapy on salivary BPIFA expression and to investigate the role of BPIFA in the development of known radiotherapy side effects.",

keywords = "Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Blotting, western, Case-control studies, Combined modality therapy, Female, Glycoproteins, Head and Neck Neoplasms, Humans, Longitudinal studies, Male, Middle aged, Phosphoproteins, Saliva, Salivary proteins and peptides",

author = "Gonz{\'a}lez-Arriagada, {Wilfredo Alejandro} and Ramos, {Lara Maria Alencar} and Silva, {Andreia Aparecida} and Vargas, {Pablo Agustin} and Coletta, {Ricardo Della} and Lynne Bingle and Lopes, {Marcio Ajudarte}",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/j.oooo.2014.09.026",

language = "English",

volume = "119",

pages = "48--58",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

issn = "2212-4403",

publisher = "Elsevier USA",

number = "1",

}

Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy. / González-Arriagada, Wilfredo Alejandro; Ramos, Lara Maria Alencar; Silva, Andreia Aparecida et al.
En: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 119, N.º 1, 01.01.2015, p. 48-58.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy

AU - González-Arriagada, Wilfredo Alejandro

AU - Ramos, Lara Maria Alencar

AU - Silva, Andreia Aparecida

AU - Vargas, Pablo Agustin

AU - Coletta, Ricardo Della

AU - Bingle, Lynne

AU - Lopes, Marcio Ajudarte

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Materials and Methods Unstimulated whole-mouth saliva was collected from 45 cancer patients (1 week before treatment, during the treatment, and 1 week after completion of radiotherapy) and from 20 controls. BPIFA1 and BPIFA2 expression was detected by western blotting and analyzed along with clinicopathologic data and side effects from the radiotherapy.Results A facial radiation field was associated with lower salivary flow during and after radiotherapy and correlated with side effects, mainly mucositis. Salivary BPIFA1 expression levels were similar between the control group and the patient group before treatment. On the other hand, BPIFA2 levels were higher in the patient group before treatment compared with the control group. BPIFA concentration was modified by radiotherapy as BPIFA1 levels increased (P =.0081) and BPIFA2 decreased (P <.0001). Higher levels of BPIFA1 were associated with the presence of mucositis (P =.0363) and its severity (P =.0500).Conclusions The present study found that levels of BPIFA1 and glycosylated forms of BPIFA2 are affected by radiotherapy, suggesting that these proteins may play a role in the oral microenvironment in irradiated patients with head and neck cancer.Objective To determine the effects of radiotherapy on salivary BPIFA expression and to investigate the role of BPIFA in the development of known radiotherapy side effects.

AB - Materials and Methods Unstimulated whole-mouth saliva was collected from 45 cancer patients (1 week before treatment, during the treatment, and 1 week after completion of radiotherapy) and from 20 controls. BPIFA1 and BPIFA2 expression was detected by western blotting and analyzed along with clinicopathologic data and side effects from the radiotherapy.Results A facial radiation field was associated with lower salivary flow during and after radiotherapy and correlated with side effects, mainly mucositis. Salivary BPIFA1 expression levels were similar between the control group and the patient group before treatment. On the other hand, BPIFA2 levels were higher in the patient group before treatment compared with the control group. BPIFA concentration was modified by radiotherapy as BPIFA1 levels increased (P =.0081) and BPIFA2 decreased (P <.0001). Higher levels of BPIFA1 were associated with the presence of mucositis (P =.0363) and its severity (P =.0500).Conclusions The present study found that levels of BPIFA1 and glycosylated forms of BPIFA2 are affected by radiotherapy, suggesting that these proteins may play a role in the oral microenvironment in irradiated patients with head and neck cancer.Objective To determine the effects of radiotherapy on salivary BPIFA expression and to investigate the role of BPIFA in the development of known radiotherapy side effects.

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Blotting, western

KW - Case-control studies

KW - Combined modality therapy

KW - Female

KW - Glycoproteins

KW - Head and Neck Neoplasms

KW - Humans

KW - Longitudinal studies

KW - Male

KW - Middle aged

KW - Phosphoproteins

KW - Saliva

KW - Salivary proteins and peptides

UR - http://www.scopus.com/inward/record.url?scp=84915818894&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2014.09.026

DO - 10.1016/j.oooo.2014.09.026

M3 - Article

C2 - 25482547

AN - SCOPUS:84915818894

SN - 2212-4403

VL - 119

SP - 48

EP - 58

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

IS - 1

ER -

Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy

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