RNAi in arthritis: Prospects of a future antisense therapy in inflammation

Maroun Khoury*, Christian Jorgensen, Florence Apparailly

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

12 Citas (Scopus)

Resumen

Rheumatoid arthritis is a chronic autoimmune disease of unknown etiology that is characterized by chronic systemic inflammation, mainly affecting the joints, leading to subsequent destruction of the cartilage and bone. RNA interference (RNAi) has been used as a remarkable new research tool to control gene expression and is ultimately envisioned to be useful in clinical treatments. The potential application of RNAi-based therapy in rheumatoid disorders is evaluated. The first successful attempts at TNFalpha silencing by local and systemic delivery of small interfering RNA in experimental arthritic models are discussed. In addition, RNAi and current biotherapies used in the clinic are compared and contrasted
Idioma originalInglés
Páginas (desde-hasta)483-489
Número de páginas7
PublicaciónCurrent Opinion in Molecular Therapeutics
Volumen9
N.º5
EstadoPublicada - 22 oct. 2007
Publicado de forma externa

Palabras clave

  • Biotherapy
  • Inflammation
  • Rheumatoid arthritis
  • RNA interference
  • TNFα

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