Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal

Medicina y ciencias biológicas

• Blast Crisis 100%
• Myeloid Progenitor Cells 99%
• Cell Self Renewal 92%
• Alternative Splicing 80%
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive 77%
• Leukemia 60%
• Protein Isoforms 59%
• Leukemia, Myeloid, Chronic Phase 33%
• Cellular Reprogramming 31%
• Proto-Oncogenes 28%
• RNA-Binding Proteins 28%
• RNA Sequence Analysis 27%
• Gene Regulatory Networks 26%
• Protein-Tyrosine Kinases 22%
• Small Interfering RNA 20%
• Exons 20%
• Monoclonal Antibodies 17%
• Maintenance 17%
• Down-Regulation 17%
• Cell Proliferation 16%
• Polymerase Chain Reaction 14%
• Therapeutics 8%