Retinoic acid in the immune system

Karina Pino-Lagos, Micah J. Benson, Randolph J. Noelle

Resultado de la investigación: Capítulo del libro/informe/acta de congresoCapítulorevisión exhaustiva

77 Citas (Scopus)

Resumen

On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (T®) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of T® function, has been the discovery that retinoic acid (RA) controls both the homing and differentiation of T®. Instantly, the wealth and breadth of knowledge of the molecular basis for RA action, its receptors, and how it controls cellular differentiation can and will be exploited to understand its profound effects on T®. Historically, vitamin A deprivation and repletion and RA agonists have been shown to profoundly affect immunity. Now these findings can be interpreted in light of the revelations that RA controls leukocyte homing and T® function.

Idioma originalInglés
Título de la publicación alojadaThe Year in Immunology 2008
EditorialBlackwell Publishing Inc.
Páginas170-187
Número de páginas18
ISBN (versión impresa)9781573317290
DOI
EstadoPublicada - nov 2008
Publicado de forma externa

Serie de la publicación

NombreAnnals of the New York Academy of Sciences
Volumen1143
ISSN (versión impresa)0077-8923
ISSN (versión digital)1749-6632

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