Retinoic acid in the immune system

Karina Pino-Lagos, Micah J. Benson, Randolph J. Noelle

Producción científica: Capítulo del libro/informe/acta de congresoCapítulorevisión exhaustiva

91 Citas (Scopus)


On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (T®) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of T® function, has been the discovery that retinoic acid (RA) controls both the homing and differentiation of T®. Instantly, the wealth and breadth of knowledge of the molecular basis for RA action, its receptors, and how it controls cellular differentiation can and will be exploited to understand its profound effects on T®. Historically, vitamin A deprivation and repletion and RA agonists have been shown to profoundly affect immunity. Now these findings can be interpreted in light of the revelations that RA controls leukocyte homing and T® function.

Idioma originalInglés
Título de la publicación alojadaThe Year in Immunology 2008
EditorialBlackwell Publishing Inc.
Número de páginas18
ISBN (versión impresa)9781573317290
EstadoPublicada - nov. 2008
Publicado de forma externa

Serie de la publicación

NombreAnnals of the New York Academy of Sciences
ISSN (versión impresa)0077-8923
ISSN (versión digital)1749-6632


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