Retinoic acid: A key player in immunity

Karina Pino-Lagos, Yanxia Guo, Randolph J. Noelle*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

60 Citas (Scopus)

Resumen

For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment.

Idioma originalInglés
Páginas (desde-hasta)430-436
Número de páginas7
PublicaciónBioFactors
Volumen36
N.º6
DOI
EstadoPublicada - nov. 2010
Publicado de forma externa

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