TY - JOUR
T1 - Repetitive fluoxetine treatment affects long-term memories but not learning
AU - Ampuero, Estibaliz
AU - Stehberg, Jimmy
AU - Gonzalez, Daniela
AU - Besser, Nicolas
AU - Ferrero, Monica
AU - Diaz-Veliz, Gabriela
AU - Wyneken, Ursula
AU - Rubio, Francisco Javier
N1 - Funding Information:
The authors thank Nataly Quezada for taking care of the animals. Funding for this study was provided by grants to U.W. from Conicyt ( Anillo ACT09_2006 ) and by Universidad de los Andes ( MED-001-09 ) to F.J.R.
PY - 2013/6/5
Y1 - 2013/6/5
N2 - Fluoxetine is currently being administered for long-term maintenance and for prophylactic reasons following the remission of depressive symptoms and several other psychiatric and neurological conditions. We have previously found that in naïve adult male rats, repetitive administration of fluoxetine induced maturation of telencephalic dendritic spines. This finding was associated with the presence of a higher proportion of GluA2- and GluN2A-containing glutamate receptors. To gain further insight into the possible consequences of such synaptic re-organization on learning and memory processes, we evaluated hippocampal- and non-hippocampal-dependent memories following administration of 0.7 mg/kg fluoxetine for four weeks. Standard behavioral tasks were used: the Morris Water Maze (MWM) and Object Location Memory (OLM) tasks to assess spatial memory and the Novel Object Recognition (NOR) task to assess recognition memory. We found that treated rats showed normal learning and short-term memory (1 h post-learning). However, either recent (24 h) or remote (17 days) memories were impaired depending upon the task. Interestingly, spatial memory impairment spontaneously reverted after 6 weeks of fluoxetine withdrawal.
AB - Fluoxetine is currently being administered for long-term maintenance and for prophylactic reasons following the remission of depressive symptoms and several other psychiatric and neurological conditions. We have previously found that in naïve adult male rats, repetitive administration of fluoxetine induced maturation of telencephalic dendritic spines. This finding was associated with the presence of a higher proportion of GluA2- and GluN2A-containing glutamate receptors. To gain further insight into the possible consequences of such synaptic re-organization on learning and memory processes, we evaluated hippocampal- and non-hippocampal-dependent memories following administration of 0.7 mg/kg fluoxetine for four weeks. Standard behavioral tasks were used: the Morris Water Maze (MWM) and Object Location Memory (OLM) tasks to assess spatial memory and the Novel Object Recognition (NOR) task to assess recognition memory. We found that treated rats showed normal learning and short-term memory (1 h post-learning). However, either recent (24 h) or remote (17 days) memories were impaired depending upon the task. Interestingly, spatial memory impairment spontaneously reverted after 6 weeks of fluoxetine withdrawal.
KW - Antidepressants
KW - Cortex
KW - Explicit memory
KW - Hippocampus
UR - http://www.scopus.com/inward/record.url?scp=84876302929&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2013.03.011
DO - 10.1016/j.bbr.2013.03.011
M3 - Article
C2 - 23511254
AN - SCOPUS:84876302929
SN - 0166-4328
VL - 247
SP - 92
EP - 100
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -