TY - JOUR
T1 - Relationship between aggressive features of oral squamous cell carcinoma and the immunoexpression of CX3CR1, CX3CL1 and ITGAV
AU - Martínez-Flores, René
AU - Lozano-Burgos, Carlo
AU - Niklander, Sven Eric
AU - Fernández-Cuya, Michelle
AU - Lopes, Márcio Ajudarte
AU - González-Arriagada, Wilfredo Alejandro
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/7/1
Y1 - 2024/7/1
N2 - OBJECTIVE: We aimed to describe the association between CX3CR1, CX3CL1, and ITGAV immunoexpression with PNI and adverse oncologic outcomes in patients with OSCC.STUDY DESIGN: Expression CX3CR1, CX3CL1, and ITGAV was assessed by immunohistochemistry in a cohort of 50 paraffin-embedded resections of OSCC. Survival analysis, Cox, and binary logistic regressions were undertaken to determine the impact on patient survival and predictive value for PNI.RESULTS: CX3CL1 positive nerves exhibited a significant association with tumor budding (TB) (P = .043), whereas nerves positive for ITGAV were associated with PNI (P = .021), T3-T4 tumor size (P = .029), and III-IV stage (P = .044). Cases with ITGAV-positive nerves exhibited an odds ratio of 9.603 (P = .008) for PNI, whereas cases with CX3CL1-positive nerves exhibited and odds ratio of 4.682 (P = .033) for TB. A trend toward decreased 5-year overall survival (P = .078) and 5-year disease-specific survival (P = .09) was observed in relation to ITGAV-positive nerves. However, no independent predictors for poor survival were identified.CONCLUSIONS: The expression of ITGAV was associated with PNI and advanced disease, whereas the expression of CX3CL1 was related to TB, suggesting that ITGAV and CX3CL1 are involved in their respective developments. Therefore, further investigations are encouraged to assess the potential utility of targeted therapies against CX3CL1 receptors in OSCC.
AB - OBJECTIVE: We aimed to describe the association between CX3CR1, CX3CL1, and ITGAV immunoexpression with PNI and adverse oncologic outcomes in patients with OSCC.STUDY DESIGN: Expression CX3CR1, CX3CL1, and ITGAV was assessed by immunohistochemistry in a cohort of 50 paraffin-embedded resections of OSCC. Survival analysis, Cox, and binary logistic regressions were undertaken to determine the impact on patient survival and predictive value for PNI.RESULTS: CX3CL1 positive nerves exhibited a significant association with tumor budding (TB) (P = .043), whereas nerves positive for ITGAV were associated with PNI (P = .021), T3-T4 tumor size (P = .029), and III-IV stage (P = .044). Cases with ITGAV-positive nerves exhibited an odds ratio of 9.603 (P = .008) for PNI, whereas cases with CX3CL1-positive nerves exhibited and odds ratio of 4.682 (P = .033) for TB. A trend toward decreased 5-year overall survival (P = .078) and 5-year disease-specific survival (P = .09) was observed in relation to ITGAV-positive nerves. However, no independent predictors for poor survival were identified.CONCLUSIONS: The expression of ITGAV was associated with PNI and advanced disease, whereas the expression of CX3CL1 was related to TB, suggesting that ITGAV and CX3CL1 are involved in their respective developments. Therefore, further investigations are encouraged to assess the potential utility of targeted therapies against CX3CL1 receptors in OSCC.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Biomarkers, Tumor/metabolism
KW - CX3C Chemokine Receptor 1/metabolism
KW - Carcinoma, Squamous Cell/metabolism
KW - Chemokine CX3CL1/metabolism
KW - Female
KW - Humans
KW - Immunohistochemistry
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms/pathology
KW - Neoplasm Invasiveness
KW - Neoplasm Staging
KW - Predictive Value of Tests
KW - Prognosis
KW - Survival Analysis
UR - http://www.scopus.com/inward/record.url?scp=85193246125&partnerID=8YFLogxK
U2 - 10.1016/j.oooo.2024.04.002
DO - 10.1016/j.oooo.2024.04.002
M3 - Article
C2 - 38760287
SN - 2212-4403
VL - 138
SP - 79
EP - 87
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 1
ER -