Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells

Keyphrases

• Mesenchymal Stem Cells 100%
• Cartilage 100%
• Regenerative Potential 100%
• Protection Potential 100%
• Δ1-pyrroline-5-carboxylate Synthetase 100%
• Mouse Mesenchymal Stem Cells 100%
• Chondrocytes 35%
• Chondrogenic Potential 17%
• Chondroprotective Effect 17%
• Expression Level 5%
• Small Interfering RNA (siRNA) 5%
• Proline 5%
• Stem Cell-derived 5%
• Reduced Expression 5%
• Differentiation Capacity 5%
• Knockdown 5%
• High-level Expression 5%
• C57BL 5%
• Overexpressing 5%
• Punching 5%
• Osteoarthritis 5%
• Metabolic Switch 5%
• Oxidative Phosphorylation (OXPHOS) 5%
• Glycolysis 5%
• Cell Surface Display 5%
• Osteoarthritis Chondrocyte 5%
• Glycolytic Potential 5%
• Regenerative Responses 5%

Biochemistry, Genetics and Molecular Biology

• Stem Cell 100%
• Oxidoreductase 100%
• Reductase 100%
• Chondrocyte 43%
• Downregulation 12%
• Induced Stem Cells 12%
• Enzyme 6%
• C57BL 6 Mouse 6%
• Oxidative Phosphorylation 6%
• Anabolism 6%
• Proline 6%
• Expression Level 6%
• Small Interfering RNA 6%
• Glycolysis 6%

Immunology and Microbiology

• Cartilage 100%
• Mesenchymal Stem Cell 100%
• Chondrocyte 38%
• Downregulation 11%
• Osteoarthritis 11%
• C57BL 6 Mouse 5%
• Oxidative Phosphorylation 5%
• Proline 5%
• Ribonucleic Acid 5%
• In Vitro 5%
• Glycolysis 5%
• Biosynthesis 5%