Primary antiphospholipid syndrome: clinical experience of 6 patients

M. Gutiérrez, F. Figueroa, L. Massardo, J. Alfaro, E. Ferreira, S. Jacobelli

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Recently, the association between anti-phospholipid antibodies (false positive VDRL, lupus anticoagulant or anti-cardiolipin antibody) and diverse clinical manifestations has been termed antiphospholipid syndrome. We report 6 female patients with "primary" antiphospholipid syndrome, not related to connective tissue disorders. Their age ranged from 23 to 66 years and they were followed from 1 to 27 years (mean 9.2). Venous occlusion developed in 4, arterial occlusion in 4 (TIA, convulsive episode and cutaneous thrombotic microangiopathy). Three of 5 had fetal loss and 3/6 developed thrombocytopenia. Leg ulcer, migraine and mitral valvulopathy and peripheral facial paralysis were isolated manifestations in different patients. High titers for type IgG anticardiolipin antibodies were present in all patients. Low titers for IgM antibodies were present in 2. The pathogenesis of this syndrome is discussed.
Idioma originalInglés estadounidense
Páginas (desde-hasta)1001-1007
Número de páginas7
PublicaciónRevista médica de Chile
Volumen119
N.º9
EstadoPublicada - 1 ene. 1991
Publicado de forma externa

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