Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus

Carlos A. Lafourcade

doi:10.1152/jn.00441.2009

Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus

Carlos A. Lafourcade

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

4 Citas (Scopus)

Resumen

Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or longlasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1α appear to be crucial, although other possibilities are emerging.

Idioma original	Inglés
Páginas (desde-hasta)	2009-2012
Número de páginas	4
Publicación	Journal of Neurophysiology
Volumen	102
N.º	4
DOI	https://doi.org/10.1152/jn.00441.2009
Estado	Publicada - oct. 2009
Publicado de forma externa	Sí

Nota bibliográfica

Palabras clave

Animals
Endocannabinoids
Gamma-Aminobutyric Acid
Hippocampus
Long-Term Synaptic Depression
Models
Neurological
Neuronal Plasticity
Neurotransmitter Agents
Presynaptic Terminals
Signal transduction
Synapses

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10.1152/jn.00441.2009

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abstract = "Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or longlasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1α appear to be crucial, although other possibilities are emerging.",

keywords = "Animals, Endocannabinoids, Gamma-Aminobutyric Acid, Hippocampus, Long-Term Synaptic Depression, Models, Neurological, Neuronal Plasticity, Neurotransmitter Agents, Presynaptic Terminals, Signal transduction, Synapses",

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AB - Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or longlasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1α appear to be crucial, although other possibilities are emerging.

KW - Animals

KW - Endocannabinoids

KW - Gamma-Aminobutyric Acid

KW - Hippocampus

KW - Long-Term Synaptic Depression

KW - Models

KW - Neurological

KW - Neuronal Plasticity

KW - Neurotransmitter Agents

KW - Presynaptic Terminals

KW - Signal transduction

KW - Synapses

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U2 - 10.1152/jn.00441.2009

DO - 10.1152/jn.00441.2009

M3 - Review article

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SN - 0022-3077

VL - 102

SP - 2009

EP - 2012

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

IS - 4

ER -

Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus

Resumen

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