Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or longlasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1α appear to be crucial, although other possibilities are emerging.
Nota bibliográficaCopyright: © 2009 The American Physiological Society.
- Gamma-Aminobutyric Acid
- Long-Term Synaptic Depression
- Neuronal Plasticity
- Neurotransmitter Agents
- Presynaptic Terminals
- Signal transduction