Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1

Michael Y. Choi; George F. Widhopf; Christina C.N. Wu; Bing Cui; Fitzgerald Lao; Anil Sadarangani; Joy Cavagnaro; Charles Prussak; Dennis A. Carson; Catriona Jamieson; Thomas J. Kipps

doi:10.1016/j.clml.2015.02.010

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1

Michael Y. Choi, George F. Widhopf, Christina C.N. Wu, Bing Cui, Fitzgerald Lao, Anil Sadarangani, Joy Cavagnaro, Charles Prussak, Dennis A. Carson, Catriona Jamieson, Thomas J. Kipps

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94 Citas (Scopus)

Resumen

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen. Because of its expression on the cell surface of leukemia cells from patients with chronic lymphocytic leukemia (CLL), but not on normal B-cells or other postpartum tissues, ROR1 is an attractive candidate for targeted therapies. UC-961 is a first-in-class humanized monoclonal antibody that binds the extracellular domain of ROR1. In this article we outline some of the preclinical studies leading to an investigational new drug designation, enabling clinical studies in patients with CLL.

Idioma original	Inglés
Número de artículo	549
Páginas (desde-hasta)	S167-S169
Publicación	Clinical Lymphoma, Myeloma and Leukemia
Volumen	15
N.º	S
DOI	https://doi.org/10.1016/j.clml.2015.02.010
Estado	Publicada - 1 jun. 2015
Publicado de forma externa	Sí

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© 2015 The Authors.

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Choi, M. Y., Widhopf, G. F., Wu, C. C. N., Cui, B., Lao, F., Sadarangani, A., Cavagnaro, J., Prussak, C., Carson, D. A., Jamieson, C., & Kipps, T. J. (2015). Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clinical Lymphoma, Myeloma and Leukemia, 15(S), S167-S169. Artículo 549. https://doi.org/10.1016/j.clml.2015.02.010

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abstract = "Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen. Because of its expression on the cell surface of leukemia cells from patients with chronic lymphocytic leukemia (CLL), but not on normal B-cells or other postpartum tissues, ROR1 is an attractive candidate for targeted therapies. UC-961 is a first-in-class humanized monoclonal antibody that binds the extracellular domain of ROR1. In this article we outline some of the preclinical studies leading to an investigational new drug designation, enabling clinical studies in patients with CLL.",

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AU - Cui, Bing

AU - Lao, Fitzgerald

AU - Sadarangani, Anil

AU - Cavagnaro, Joy

AU - Prussak, Charles

AU - Carson, Dennis A.

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AB - Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen. Because of its expression on the cell surface of leukemia cells from patients with chronic lymphocytic leukemia (CLL), but not on normal B-cells or other postpartum tissues, ROR1 is an attractive candidate for targeted therapies. UC-961 is a first-in-class humanized monoclonal antibody that binds the extracellular domain of ROR1. In this article we outline some of the preclinical studies leading to an investigational new drug designation, enabling clinical studies in patients with CLL.

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Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1

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