PPARβ/δ: A master regulator of mesenchymal stem cell functions

Farida Djouad, Natacha Ipseiz, Patricia Luz-Crawford, Carina Scholtysek, Gerhard Krönke, Christian Jorgensen

Resultado de la investigación: Contribución a una revistaEstudio breverevisión exhaustiva

3 Citas (Scopus)

Resumen

Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.

Idioma originalInglés
Páginas (desde-hasta)55-58
Número de páginas4
PublicaciónBiochimie
Volumen136
DOI
EstadoPublicada - 1 may 2017

Nota bibliográfica

Publisher Copyright:
© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)

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