PPARβ/δ: A master regulator of mesenchymal stem cell functions

Farida Djouad; Natacha Ipseiz; Patricia Luz-Crawford; Carina Scholtysek; Gerhard Krönke; Christian Jorgensen

doi:10.1016/j.biochi.2016.11.011

PPARβ/δ: A master regulator of mesenchymal stem cell functions

Farida Djouad^*, Natacha Ipseiz, Patricia Luz-Crawford, Carina Scholtysek, Gerhard Krönke, Christian Jorgensen

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Estudio breve › revisión exhaustiva

9 Citas (Scopus)

Resumen

Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.

Idioma original	Inglés
Páginas (desde-hasta)	55-58
Número de páginas	4
Publicación	Biochimie
Volumen	136
DOI	https://doi.org/10.1016/j.biochi.2016.11.011
Estado	Publicada - 1 may. 2017

Nota bibliográfica

Publisher Copyright:
© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)

Palabras clave

Animals
Humans
Immune tolerance
mesenchymal stromal cells
Osteogenesis
PPAR gamma
PPAR-beta

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10.1016/j.biochi.2016.11.011

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title = "PPARβ/δ: A master regulator of mesenchymal stem cell functions",

abstract = "Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.",

keywords = "Animals, Humans, Immune tolerance, mesenchymal stromal cells, Osteogenesis, PPAR gamma, PPAR-beta",

author = "Farida Djouad and Natacha Ipseiz and Patricia Luz-Crawford and Carina Scholtysek and Gerhard Kr{\"o}nke and Christian Jorgensen",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V. and Soci{\'e}t{\'e} Fran{\c c}aise de Biochimie et Biologie Mol{\'e}culaire (SFBBM)",

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doi = "10.1016/j.biochi.2016.11.011",

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TY - JOUR

T1 - PPARβ/δ

T2 - A master regulator of mesenchymal stem cell functions

AU - Djouad, Farida

AU - Ipseiz, Natacha

AU - Luz-Crawford, Patricia

AU - Scholtysek, Carina

AU - Krönke, Gerhard

AU - Jorgensen, Christian

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.

AB - Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.

KW - Animals

KW - Humans

KW - Immune tolerance

KW - mesenchymal stromal cells

KW - Osteogenesis

KW - PPAR gamma

KW - PPAR-beta

UR - http://www.scopus.com/inward/record.url?scp=85007518385&partnerID=8YFLogxK

U2 - 10.1016/j.biochi.2016.11.011

DO - 10.1016/j.biochi.2016.11.011

M3 - Short survey

C2 - 27914902

AN - SCOPUS:85007518385

SN - 0300-9084

VL - 136

SP - 55

EP - 58

JO - Biochimie

JF - Biochimie

ER -

PPARβ/δ: A master regulator of mesenchymal stem cell functions

Resumen

Nota bibliográfica

Palabras clave

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