TY - JOUR
T1 - Potential therapeutic uses of intraoral mesenchymal stem cells in other tissues of the body
T2 - A review
AU - Villarroel, Valentina
AU - Fagalde, Pascale
AU - Reininger, David
N1 - Publisher Copyright:
© 2021. Medicina Oral S. L. C.I.F. B 96689336 - elSSN: 1989-5488.
PY - 2021
Y1 - 2021
N2 - Background: Over the last few years, there has been a great advance in regenerative medicine, with various studies that have observed the ability to repair or regenerate dysfunctional tissues with the patient’s own cells, such as with mesenchymal cells. In this area, mesenchymal stem cells (MSCs) from the oral cavity have attracted attention because of their easy access and multiple cellular differentiations. Multiple studies have shown the various clinical applications at the intraoral level, especially at the level of bone regeneration, but the potential applications of oral MSC at a systemic level have been scarcely described. Objective: The objective of this review was to describe the potential therapeutic uses of intraoral MSCs in other tissues of the organism. Material and Methods: A review of the literature between 2000 and 2019. Only included those studies done on animals or humans. Results: Twenty five articles were selected, all performed on animals. The donor site most used were the temporary teeth exfoliated from humans, representing 56% of the total articles, followed by the dental pulp with 28% of the total articles included. Transplantation of intraoral mesenchymal cells in animals with neural tissue illness was the most studied therapy. Conclusions: Although obtaining MSC of intraoral origin has proven to be a good alternative in regenerative medicine, achieving therapeutic uses in bone tissue, nervous tissue, liver tissue, skin tissue, ocular tissue, reperfusion of tissues and in autoimmune diseases, there is a lack of clinical studies that allow its safe use in humans.
AB - Background: Over the last few years, there has been a great advance in regenerative medicine, with various studies that have observed the ability to repair or regenerate dysfunctional tissues with the patient’s own cells, such as with mesenchymal cells. In this area, mesenchymal stem cells (MSCs) from the oral cavity have attracted attention because of their easy access and multiple cellular differentiations. Multiple studies have shown the various clinical applications at the intraoral level, especially at the level of bone regeneration, but the potential applications of oral MSC at a systemic level have been scarcely described. Objective: The objective of this review was to describe the potential therapeutic uses of intraoral MSCs in other tissues of the organism. Material and Methods: A review of the literature between 2000 and 2019. Only included those studies done on animals or humans. Results: Twenty five articles were selected, all performed on animals. The donor site most used were the temporary teeth exfoliated from humans, representing 56% of the total articles, followed by the dental pulp with 28% of the total articles included. Transplantation of intraoral mesenchymal cells in animals with neural tissue illness was the most studied therapy. Conclusions: Although obtaining MSC of intraoral origin has proven to be a good alternative in regenerative medicine, achieving therapeutic uses in bone tissue, nervous tissue, liver tissue, skin tissue, ocular tissue, reperfusion of tissues and in autoimmune diseases, there is a lack of clinical studies that allow its safe use in humans.
KW - dental component
KW - Mesenchymal stem cells
KW - regenerative medicine
KW - stem cell transplantation
UR - http://www.scopus.com/inward/record.url?scp=85102819901&partnerID=8YFLogxK
U2 - 10.4317/JCED.56809
DO - 10.4317/JCED.56809
M3 - Article
AN - SCOPUS:85102819901
SN - 1989-5488
VL - 13
SP - e259-e267
JO - Journal of Clinical and Experimental Dentistry
JF - Journal of Clinical and Experimental Dentistry
IS - 3
ER -