PLA/PGA and its co-Polymers in Alveolar Bone Regeneration.: A Systematic Review

Marcelo Parra; María Paz Moya; Carolina Rebolledo; Ziyad S Haidar; Juan Pablo Alister; Sergio Olate

doi:10.4067/S0718-381X2019000300258

PLA/PGA and its co-Polymers in Alveolar Bone Regeneration. A Systematic Review

Título traducido de la contribución: PLA/PGA y sus Copolímeros en Regeneración Ósea Alveolar.: Una Revisión Sistemática

Marcelo Parra
, María Paz Moya
, Carolina Rebolledo
, Ziyad S Haidar
, Juan Pablo Alister
, Sergio Olate^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

126 Descargas (Pure)

Resumen

RESUMEN: El objetivo de esta revisión fue realizar una revisión sistemática de la literatura para identificar los usos más frecuentes de PLA/PGA en regeneración ósea en área maxilofacial y sus resultados. Se diseñó un estudio para responder a la pregunta: ¿Cuáles son los usos más frecuentes de PLA/PLGA y sus copolímeros en regeneración ósea en el sector maxilofacial?. Los estudios seleccionados fueron en su mayoría débiles y sobre los usos más frecuentes de PLA/PGA, 13 estudios lo utilizaron como membrana reabsorbible, 2 estudios como malla absorbible, un estudio como tornillo absorbible y 3 estudios como material de relleno. En base a nuestros resultados, los autores estiman que PLA/PGA requiere una delicada relación entre la resistencia mecánica que ofrece y la degradación que se produce; PLA/ PGA no interrumpe la regeneración ósea, sin embargo, no se ha identificado la potencialidad o influencia que presenta en los eventos celulares de la regeneración y posterior oseointegración.

Título traducido de la contribución	PLA/PGA y sus Copolímeros en Regeneración Ósea Alveolar.: Una Revisión Sistemática
Idioma original	Inglés
Páginas (desde-hasta)	258-265
Número de páginas	8
Publicación	International journal of odontostomatology
Volumen	13
N.º	3
DOI	https://doi.org/10.4067/S0718-381X2019000300258
Estado	Publicada - 9 ago. 2019

Palabras clave

injerto óseo
PLA/PGA
sustituto óseo

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@article{c4654323c9514b759752433891334d59,

title = "PLA/PGA and its co-Polymers in Alveolar Bone Regeneration.: A Systematic Review",

abstract = "ABSTRACT: The aim of this research was to perform a systematic review to identify the most frequent uses of PLA/ PGA in alveolar bone regeneration and their results. A study was designed to answer the question: What are the most frequent uses of PLA/PLGA and their copolymers in alveolar bone regeneration?. A systematic search was done on MEDLINE, EMBASE and LILACS from April 1993 to December 2017. The search string used on MEDLINE was: (((polylactic acid) OR PLA) OR PLA-based copolymers) OR PLA blends) OR PLA scaffolds)) AND ((({"}Bone Regeneration{"}[Mesh]) OR bone regeneration) OR guided bone regeneration). The search was complemented by a manual review of the references from the articles included. Most of the studies selected were weak and, regarding the most frequent uses of PLA/PGA, 13 studies used it as a resorbable membrane, two as an absorbable mesh, one as an absorbable screw and three as filling material. Based on our results, the authors consider that PLA/PGA requires a delicate relation between the mechanical resistance and the degradation process. PLA/PGA does not interrupt bone regeneration; however, the influence in cellular events related to bone regeneration and later osseointegration have not been identified.",

keywords = "poly lactic acid poly ethylene glycol, bone substitute, bone grafting, injerto {\'o}seo, PLA/PGA, sustituto {\'o}seo",

author = "Marcelo Parra and Moya, \{Mar{\'i}a Paz\} and Carolina Rebolledo and Haidar, \{Ziyad S\} and Alister, \{Juan Pablo\} and Sergio Olate",

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doi = "10.4067/S0718-381X2019000300258",

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AU - Moya, María Paz

AU - Rebolledo, Carolina

AU - Haidar, Ziyad S

AU - Alister, Juan Pablo

AU - Olate, Sergio

PY - 2019/8/9

Y1 - 2019/8/9

N2 - ABSTRACT: The aim of this research was to perform a systematic review to identify the most frequent uses of PLA/ PGA in alveolar bone regeneration and their results. A study was designed to answer the question: What are the most frequent uses of PLA/PLGA and their copolymers in alveolar bone regeneration?. A systematic search was done on MEDLINE, EMBASE and LILACS from April 1993 to December 2017. The search string used on MEDLINE was: (((polylactic acid) OR PLA) OR PLA-based copolymers) OR PLA blends) OR PLA scaffolds)) AND ((("Bone Regeneration"[Mesh]) OR bone regeneration) OR guided bone regeneration). The search was complemented by a manual review of the references from the articles included. Most of the studies selected were weak and, regarding the most frequent uses of PLA/PGA, 13 studies used it as a resorbable membrane, two as an absorbable mesh, one as an absorbable screw and three as filling material. Based on our results, the authors consider that PLA/PGA requires a delicate relation between the mechanical resistance and the degradation process. PLA/PGA does not interrupt bone regeneration; however, the influence in cellular events related to bone regeneration and later osseointegration have not been identified.

AB - ABSTRACT: The aim of this research was to perform a systematic review to identify the most frequent uses of PLA/ PGA in alveolar bone regeneration and their results. A study was designed to answer the question: What are the most frequent uses of PLA/PLGA and their copolymers in alveolar bone regeneration?. A systematic search was done on MEDLINE, EMBASE and LILACS from April 1993 to December 2017. The search string used on MEDLINE was: (((polylactic acid) OR PLA) OR PLA-based copolymers) OR PLA blends) OR PLA scaffolds)) AND ((("Bone Regeneration"[Mesh]) OR bone regeneration) OR guided bone regeneration). The search was complemented by a manual review of the references from the articles included. Most of the studies selected were weak and, regarding the most frequent uses of PLA/PGA, 13 studies used it as a resorbable membrane, two as an absorbable mesh, one as an absorbable screw and three as filling material. Based on our results, the authors consider that PLA/PGA requires a delicate relation between the mechanical resistance and the degradation process. PLA/PGA does not interrupt bone regeneration; however, the influence in cellular events related to bone regeneration and later osseointegration have not been identified.

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KW - bone substitute

KW - bone grafting

KW - injerto óseo

KW - PLA/PGA

KW - sustituto óseo

U2 - 10.4067/S0718-381X2019000300258

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M3 - Article

VL - 13

SP - 258

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JO - International journal of odontostomatology

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IS - 3

ER -

PLA/PGA and its co-Polymers in Alveolar Bone Regeneration. A Systematic Review

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