Pharmacogenetics in Psychiatry: Perceived Value and Opinions in a Chilean Sample of Practitioners

Juan Undurraga, Ignacio Bórquez-Infante, Nicolás A. Crossley, Miguel Prieto, Gabriela M. Repetto*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Use of pharmacogenetics (PGx) testing to guide clinical decisions is growing in developed countries. Published guidelines for gene–drug pair analysis are available for prescriptions in psychiatry, but information on their utilization, barriers, and health outcomes in Latin America is limited. As a result, this work aimed at exploring current use, opinions, and perceived obstacles on PGx testing among psychiatrists in Chile, via an online, anonymous survey. Among 123 respondents (5.9% of registered psychiatrists in the country), 16.3% reported ever requesting a PGx test. The vast majority (95%) of tests were ordered by clinicians practicing in the Metropolitan Region of Santiago. Having more than 20 years in practice was positively associated with prior use of PGx (p 0.02, OR 3.74 (1.19–11.80)), while working in the public health system was negatively associated (OR 0.30 (0.10–0.83)). Perceived barriers to local implementation included insufficient evidence of clinical utility, limited clinicians’ knowledge on PGx and on test availability, and health systems’ issues, such as costs and reimbursement. Despite the recognition of these barriers, 80% of respondents asserted that it is likely that they will incorporate PGx tests in their practice in the next five years. Given these results, we propose next steps to facilitate implementation such as further research in health outcomes and clinical utility of known and novel clinically actionable variants, growth in local sequencing capabilities, education of clinicians, incorporation of clinical decision support tools, and economic evaluations, all in local context.

Idioma originalInglés
Número de artículo657985
Páginas (desde-hasta)657985
PublicaciónFrontiers in Pharmacology
Volumen12
DOI
EstadoPublicada - 15 abr 2021

Nota bibliográfica

Publisher Copyright:
© Copyright © 2021 Undurraga, Bórquez-Infante, Crossley, Prieto and Repetto.

Funding Information:
Supported in part by ANID-PIA-ACT192064 (JU, NC, GMR), FONDECYT 1180358 (JU), 1200601 (NAC), 1171014 (GMR), 1181365 (MLP), FONDEF ID19I10116 (MLP) and Clínica Alemana de Santiago ID 863 (JU). Funding for researchers’ time. and publication fees The agencies had no role in study design, analysis, interpretation of results, or manuscript writing.

Publisher Copyright:
© Copyright © 2021 Undurraga, Bórquez-Infante, Crossley, Prieto and Repetto.

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