Pesquiza precoz de nefropatía diabética en niños y adolescentes portadores de diabetes mellitus tipo 1

Vivian Gallardo T.*, Francisca Ugarte P., Antonio Barrera N., Claudia Godoy C., Ana Pereira S., Elizabeth Eblen Z.

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

4 Citas (Scopus)

Resumen

Introduction: Diabetic nephropathy commences early after the diagnosis of type 1 DM, described risk factors include time after diagnosis, deficient metabolic control, puberty and arterial hypertension. Objective: To evaluate the aforementioned parameters and their association with early renal compromise in children with type 1 DM. Methods: Prospective study measuring microalbuminuria, random morning creatininuria (index microalbuminuria/creatininuria (ACR), plasma creatinine, creatinine clearence, renal ultrasound, actual glycosylated hemoglobin and previous average, age of diagnosis, puberty and blood pressure. Results: 44 patients were studied, 20 males, average age 11.68 ± 3.01 years, with a follow-up since DM diagnosis of 3.8 ± 2.84 years. Average HbA1c was 9.1 ± 1.9%. Hyperfiltration was observed in 7/44 (15.9%) and nephromegalia was noted in 7/28 (25%). 8/44 patients (18,2%) had a raised ACR, and the 25% of prepuberal patients who has increase ACR were diagnosed at an earlier age. There was no correlation between metabolic control, hyperfiltration or nephromegalia with other studied parameters. Conclusions: Microalbuminuria determined by ACR is present in 18.2% of patients, presented more frequent in prepuberal children who debut at youngest age, being a possible risk factor for its future development.
Título traducido de la contribuciónEarly detection of diabetic nephropathy in children and adolescents with type 1 diabetes mellitus
Idioma originalEspañol
Páginas (desde-hasta)252-258
Número de páginas7
PublicaciónRevista Chilena de Pediatria
Volumen76
N.º3
EstadoPublicada - jun. 2005
Publicado de forma externa

Palabras clave

  • Diabetic nephropathy
  • Early diagnosis
  • Microalbuminuria

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