Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Alerie Guzman De La Fuente, Simona Lange, Maria Elena Silva, Ginez A. Gonzalez, Herbert Tempfer, Peter van Wijngaarden, Chao Zhao, Ludovica Di Canio, Andrea Trost, Lara Bieler, Pia Zaunmair, Peter Rotheneichner, Anna O'Sullivan, Sebastien Couillard-Despres, Oihana Errea, Maarja A. Mäe, Johanna Andrae, Liqun He, Annika Keller, Luis Federico BatizChrister Betsholtz, Ludwig Aigner, Robin J.M. Franklin, Francisco J. Rivera

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

51 Citas (Scopus)

Resumen

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.

Idioma originalInglés
Páginas (desde-hasta)1755-1764
Número de páginas10
PublicaciónCell Reports
Volumen20
N.º8
DOI
EstadoPublicada - 22 ago 2017

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© 2017 The Authors

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