TY - JOUR
T1 - Pathogenesis of preeclampsia
T2 - The genetic component
AU - Valenzuela, Francisco J.
AU - Pérez-Sepúlveda, Alejandra
AU - Torres, María J.
AU - Correa, Paula
AU - Repetto, Gabriela M.
AU - Illanes, Sebastián E.
N1 - © 2012 Francisco J. Valenzuela et al.
PY - 2012
Y1 - 2012
N2 - Preeclampsia (PE) is one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40 of births delivered before 35 weeks of gestation. PE begins with inadequate trophoblast invasion early in pregnancy, which produces an increase in oxidative stress contributing to the development of systemic endothelial dysfunction in the later phases of the disease, leading to the characteristic clinical manifestation of PE. Numerous methods have been used to predict the onset of PE with different degrees of efficiency. These methods have used fetal/placental and maternal markers in different stages of pregnancy. From an epidemiological point of view, many studies have shown that PE is a disease with a strong familiar predisposition, which also varies according to geographical, socioeconomic, and racial features, and this information can be used in the prediction process. Large amounts of research have shown a genetic association with a multifactorial polygenic inheritance in the development of this disease. Many biological candidate genes and polymorphisms have been examined in their relation with PE. We will discuss the most important of them, grouped by the different pathogenic mechanisms involved in PE.
AB - Preeclampsia (PE) is one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40 of births delivered before 35 weeks of gestation. PE begins with inadequate trophoblast invasion early in pregnancy, which produces an increase in oxidative stress contributing to the development of systemic endothelial dysfunction in the later phases of the disease, leading to the characteristic clinical manifestation of PE. Numerous methods have been used to predict the onset of PE with different degrees of efficiency. These methods have used fetal/placental and maternal markers in different stages of pregnancy. From an epidemiological point of view, many studies have shown that PE is a disease with a strong familiar predisposition, which also varies according to geographical, socioeconomic, and racial features, and this information can be used in the prediction process. Large amounts of research have shown a genetic association with a multifactorial polygenic inheritance in the development of this disease. Many biological candidate genes and polymorphisms have been examined in their relation with PE. We will discuss the most important of them, grouped by the different pathogenic mechanisms involved in PE.
KW - Female
KW - Genetic Association Studies
KW - Genetic Markers
KW - Genetic Predisposition to Disease
KW - Humans
KW - Polymorphism
KW - Genetic
KW - pre-eclampsia
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=84865730407&partnerID=8YFLogxK
U2 - 10.1155/2012/632732
DO - 10.1155/2012/632732
M3 - Review article
C2 - 22175024
AN - SCOPUS:84865730407
SN - 2090-2727
VL - 2012
JO - Journal of Pregnancy
JF - Journal of Pregnancy
M1 - 632732
ER -