Passage of albumin from the middle ear to the inner ear in otitis media in the chinchilla

Burt Goldberg, Marcus V. Goycoolea, Patrick M. Schleivert, Donald Shea, Patricia Schachern, Michael M. Paparella, Anna Maria Carpenter

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

35 Citas (Scopus)

Resumen

A study of the permeability of the middle ear-inner ear interface for macromolecules was carried out in chinchillas with open and obstructed eustachian tubes utilizing tritiated human serum albumin and immunoelectrophoresis. Tritiated albumin was placed in the round window niche area of normal animals and animals in which the eustachian tubes had been obstructed for 24 hours or 14 days. The tritiated albumin was allowed to remain in the middle ear cavity for 24 hours. Samples of middle ear effusion, perilymph, blood and cerebrospinal fluid were collected and measured for radioactivity. Radioactivity was demonstrated in the perilymph. Samples of middle ear effusions and perillymph were also studied by immunoelectrophoresis with goat antihuman albumin. Albumin placed in the round window niche of an experimental animal could be recovered unchanged in the perilymph. The results suggest a pathophysiologic explanation for the association of otitis media and sensorineural hearing loss or endolymphatic hydrops.
Idioma originalInglés
Páginas (desde-hasta)210-214
Número de páginas5
PublicaciónAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volumen2
N.º3
DOI
EstadoPublicada - ago. 1981

Nota bibliográfica

Publisher Copyright: © 1981

Palabras clave

  • Animals
  • Chinchilla
  • Humans
  • Immunoelectrophoresis
  • Labyrinthine fluids
  • Otitis media
  • Perilymph
  • Permeability
  • Round Window
  • Serum Albumin
  • Tritium

Huella

Profundice en los temas de investigación de 'Passage of albumin from the middle ear to the inner ear in otitis media in the chinchilla'. En conjunto forman una huella única.

Citar esto