TY - JOUR
T1 - Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.
AU - Chaparro, Alejandra
AU - Sanz, Antonio
AU - Wolnitzky, Andrei
AU - Realini, Ornella
AU - Bendek, María José
AU - Betancur, Daniel
AU - Albers, Daniela
AU - Beltrán, Víctor
N1 - Funding Information:
Acknowledgements: This study was funded by Proyecto RE?I170658, CONICYT-Chile and the Innovation Contest "Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes” resolution code No. 0468.
Funding Information:
This study was funded by Proyecto REDI170658, CONICYT-Chile and the Innovation Contest "Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes? resolution code No. 0468.
Publisher Copyright:
© 2020, Universidad de Concepcion. All rights reserved.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.
AB - Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.
KW - Chemokine ccl20
KW - Enzyme-linked immunosorbent assay
KW - Gingival crevicular fluid
KW - Mucositis
KW - Peri-implantitis
KW - RANK ligand
UR - http://www.scopus.com/inward/record.url?scp=85094667593&partnerID=8YFLogxK
U2 - 10.17126/JORALRES.2020.029
DO - 10.17126/JORALRES.2020.029
M3 - Article
AN - SCOPUS:85094667593
SN - 0719-2460
VL - 2020
SP - 20
EP - 25
JO - Journal of Oral Research
JF - Journal of Oral Research
IS - Special Issue 1
ER -