Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

G. Sydow-Plum; Z.S. Haidar; Y. Merhi; M. Tabrizian

doi:10.3390/ma1010025

Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

G. Sydow-Plum, Z.S. Haidar, Y. Merhi, M. Tabrizian^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

5 Citas (Scopus)

Resumen

Membrane-covered Express2TM Monorail® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs.

Idioma original	Inglés
Páginas (desde-hasta)	25-43
Número de páginas	19
Publicación	Materials
Volumen	1
N.º	1
DOI	https://doi.org/10.3390/ma1010025
Estado	Publicada - dic. 2008
Publicado de forma externa	Sí

Nota bibliográfica

Publisher Copyright:
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

Acceder al documento

10.3390/ma1010025

http://adsabs.harvard.edu/abs/2008Mate....1...25S

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{237f8def652b41b1a082c9a3ff71767f,

title = "Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies",

abstract = "Membrane-covered Express2TM Monorail{\textregistered} stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs. ",

keywords = "Chitosan, Controlled drug release, Hyaluronic acid, Paclitaxel, Polyethylene oxide, Restenosis, Stent, Thrombogenecity",

author = "G. Sydow-Plum and Z.S. Haidar and Y. Merhi and M. Tabrizian",

note = "Publisher Copyright: {\textcopyright} 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.",

year = "2008",

month = dec,

doi = "10.3390/ma1010025",

language = "English",

volume = "1",

pages = "25--43",

journal = "Materials",

issn = "1996-1944",

publisher = "MDPI AG",

number = "1",

}

TY - JOUR

T1 - Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

AU - Sydow-Plum, G.

AU - Haidar, Z.S.

AU - Merhi, Y.

AU - Tabrizian, M.

PY - 2008/12

Y1 - 2008/12

N2 - Membrane-covered Express2TM Monorail® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs.

AB - Membrane-covered Express2TM Monorail® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs.

KW - Chitosan

KW - Controlled drug release

KW - Hyaluronic acid

KW - Paclitaxel

KW - Polyethylene oxide

KW - Restenosis

KW - Stent

KW - Thrombogenecity

UR - http://www.scopus.com/inward/record.url?scp=77953993246&partnerID=8YFLogxK

U2 - 10.3390/ma1010025

DO - 10.3390/ma1010025

M3 - Article

AN - SCOPUS:77953993246

SN - 1996-1944

VL - 1

SP - 25

EP - 43

JO - Materials

JF - Materials

IS - 1

ER -

Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

Resumen

Nota bibliográfica

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto