Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

Georg Sydow-Plum, Ziyad S. Haidar, Yahye Merhi, Maryam Tabrizian

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)

Resumen

Membrane-covered Express2TM Monorail® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs
Idioma originalInglés
Páginas (desde-hasta)25-43
Número de páginas19
PublicaciónMaterials
Volumen1
N.º1
DOI
EstadoPublicada - 7 nov. 2008

Nota bibliográfica

Publisher Copyright:
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

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