miRNAs of Astrocyte-Derived Small Extracellular Vesicles Potentially Modulate Adult Neurogenesis Under Stress Conditions

Felipe Bustamante, Maxs Méndez-Ruette, Ursula Wyneken, Luis Federico Bátiz, Roberto Henzi

Resultado de la investigación: Capítulo del libro/informe/acta de congresoCapítulorevisión exhaustiva

Resumen

Stressful conditions can alter neurogenesis in the dentate gyrus of the hippocampus, but the mechanisms underlying this phenomenon remain unclear. It is well known that astrocytes form nodal points that connect the systemic signals with the microenvironment of the neurogenic niche; they can interact with adult neural stem and progenitor cells (NSPCs) either through cell-cell contact or by the release of soluble factors for modulating their biology. In this regard the latest evidence suggests that astrocyte-derived small extracellular vesicles (sEVs) may be essential. Different biologically active molecules have been described as integral components of sEVs, including miRNAs, whose deregulation could generate a reduced proliferative/self-renewal potential and defective neurogenesis, as well as aberrant migration of neuroblasts/immature neurons. In this chapter, we review the current knowledge about how stressful conditions alter the hippocampal neurogenesis and how astrocyte-derived sEVs are involved, making special focus on their miRNA cargo.

Idioma originalInglés
Título de la publicación alojadaStress: Genetics, Epigenetics and Genomics
EditoresGeorge Fink
EditorialAcademic Press Inc.
Capítulo16
Páginas179-193
Número de páginas15
Volumen4
ISBN (versión digital)9780128131565
ISBN (versión impresa)978-0-12-813156-5
DOI
EstadoPublicada - 1 ene. 2020

Serie de la publicación

NombreStress: Genetics, Epigenetics and Genomics

Nota bibliográfica

Publisher Copyright:
© 2021 Elsevier Inc.

Palabras clave

  • miRNAs
  • Extracellular vesicles
  • Neurogenesis

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