miRNAs of Astrocyte-Derived Small Extracellular Vesicles Potentially Modulate Adult Neurogenesis Under Stress Conditions

Maxs Méndez, Luis Federico Batiz, Úrsula Wyneken, Roberto Henzi*, Felipe A. Bustamante-Barrientos

*Autor correspondiente de este trabajo

Resultado de la investigación: Capítulo del libro/informe/acta de congresoCapítulorevisión exhaustiva

Resumen

Stressful conditions can alter neurogenesis in the dentate gyrus of the hippocampus, but the mechanisms underlying this phenomenon remain unclear. It is well known that astrocytes form nodal points that connect the systemic signals with the microenvironment of the neurogenic niche; they can interact with adult neural stem and progenitor cells (NSPCs) either through cell–cell contact or by the release of soluble factors for modulating their biology. In this regard the latest evidence suggests that astrocyte-derived small extracellular vesicles (sEVs) may be essential. Different biologically active molecules have been described as integral components of sEVs, including miRNAs, whose deregulation could generate a reduced proliferative/self-renewal potential and defective neurogenesis, as well as aberrant migration of neuroblasts/immature neurons. In this chapter, we review the current knowledge about how stressful conditions alter the hippocampal neurogenesis and how astrocyte-derived sEVs are involved, making special focus on their miRNA cargo
Idioma originalInglés
Título de la publicación alojadaStress: Genetics, Epigenetics and Genomics
EditoresGeorge Fink
EditorialAcademic Press Inc.
Capítulo16
Páginas179-193
Número de páginas15
ISBN (versión impresa)978-0-12-813156-5
DOI
EstadoPublicada - 2021

Serie de la publicación

NombreStress: Genetics, Epigenetics and Genomics

Palabras clave

  • miRNAs
  • Extracellular vesicles
  • Neurogenesis

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