Microrna profiling of b cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkers

Isabelle Duroux-Richard*, Jimena Cuenca, Clara Ponsolles, Alejandro Badilla Piñeiro, Fernando Gonzalez, Christine Roubert, Roser Areny, Rosa Chea, Jacqueline Pefaur, Yves Marie Pers, Fernando E. Figueroa, Christian Jorgensen, Maroun Khoury, Florence Apparailly

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

25 Citas (Scopus)

Resumen

MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE). However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvement, as well as heterogeneous cell populations. Here, we aimed at identifying a miRNA signature of purified B cells from renal and non-renal severe SLE patients of Latin American background, a population known to express severe disease. Genome-wide miRNA expression analyses were performed on naive and memory B cells and revealed two categories of miRNA signatures. The first signature represents B cell subset-specific miRNAs deregulated in SLE: 11 and six miRNAs discriminating naive and memory B cells of SLE patients from healthy controls (HC), respectively. Whether the miRNA was up or down-regulated in memory B cells as compared with naive B cells in HC, this difference was abolished in SLE patients, and vice versa. The second signature identifies six miRNAs associated with specific pathologic features affecting renal outcome, providing a further understanding for SLE pathogenesis. Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE.
Idioma originalInglés
Páginas (desde-hasta)16953-16965
Número de páginas13
PublicaciónInternational Journal of Molecular Sciences
Volumen16
N.º8
DOI
EstadoPublicada - 2015

Nota bibliográfica

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

Huella

Profundice en los temas de investigación de 'Microrna profiling of b cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkers'. En conjunto forman una huella única.

Citar esto