Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: Multicentre study from the Prospective Lynch Syndrome Database

Prospective Lynch Syndrome Database

doi:10.1093/bjs/znaf061

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: Multicentre study from the Prospective Lynch Syndrome Database

Prospective Lynch Syndrome Database

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.

Idioma original	Inglés
Número de artículo	znaf061
Publicación	British Journal of Surgery
Volumen	112
N.º	4
DOI	https://doi.org/10.1093/bjs/znaf061
Estado	Publicada - 1 abr. 2025

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@article{75e5f949457e48cf93ce6895620a1cd5,

title = "Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: Multicentre study from the Prospective Lynch Syndrome Database",

abstract = "This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path\_MLH1, path\_MSH2, and path\_MSH6 carriers compared to segmental resection.",

author = "\{Prospective Lynch Syndrome Database\} and K. Zalevskaja and K. Ojala and A. Petrov and S. Haupt and L. Sunde and I. Bernstein and Jenkins, \{M. A.\} and S. Aretz and M. Nielsen and G. Capella and F. Balaguer and Evans, \{D. G.\} and J. Burn and E. Holinski-Feder and L. Bertario and B. Bonanni and A. Lindblom and Z. Levi and F. MacRae and I. Winship and Plazzer, \{J. P.\} and R. Sijmons and L. Laghi and \{Della Valle\}, A. and K. Heinimann and T. D{\c e}bniak and R. Fruscio and F. Lopez-Koestner and K. Alvarez-Valenzuela and Katz, \{L. H.\} and I. Laish and E. Vainer and C. Vaccaro and Carraro, \{D. M.\} and K. Monahan and E. Half and A. Stakelum and D. Winter and R. Kennelly and N. Gluck and H. Sheth and N. Abu-Freha and M. Greenblatt and Rossi, \{B. M.\} and M. Bohorquez and Cavestro, \{G. M.\} and Lino-Silva, \{L. S.\} and K. Horisberger and Tibiletti, \{M. G.\} and \{Do Nascimento\}, I.",

year = "2025",

month = apr,

day = "1",

doi = "10.1093/bjs/znaf061",

language = "English",

volume = "112",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "Oxford University Press",

number = "4",

}

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: Multicentre study from the Prospective Lynch Syndrome Database. / Prospective Lynch Syndrome Database.
En: British Journal of Surgery, Vol. 112, N.º 4, znaf061, 01.04.2025.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome

T2 - Multicentre study from the Prospective Lynch Syndrome Database

AU - Prospective Lynch Syndrome Database

AU - Zalevskaja, K.

AU - Ojala, K.

AU - Petrov, A.

AU - Haupt, S.

AU - Sunde, L.

AU - Bernstein, I.

AU - Jenkins, M. A.

AU - Aretz, S.

AU - Nielsen, M.

AU - Capella, G.

AU - Balaguer, F.

AU - Evans, D. G.

AU - Burn, J.

AU - Holinski-Feder, E.

AU - Bertario, L.

AU - Bonanni, B.

AU - Lindblom, A.

AU - Levi, Z.

AU - MacRae, F.

AU - Winship, I.

AU - Plazzer, J. P.

AU - Sijmons, R.

AU - Laghi, L.

AU - Della Valle, A.

AU - Heinimann, K.

AU - Dębniak, T.

AU - Fruscio, R.

AU - Lopez-Koestner, F.

AU - Alvarez-Valenzuela, K.

AU - Katz, L. H.

AU - Laish, I.

AU - Vainer, E.

AU - Vaccaro, C.

AU - Carraro, D. M.

AU - Monahan, K.

AU - Half, E.

AU - Stakelum, A.

AU - Winter, D.

AU - Kennelly, R.

AU - Gluck, N.

AU - Sheth, H.

AU - Abu-Freha, N.

AU - Greenblatt, M.

AU - Rossi, B. M.

AU - Bohorquez, M.

AU - Cavestro, G. M.

AU - Lino-Silva, L. S.

AU - Horisberger, K.

AU - Tibiletti, M. G.

AU - Do Nascimento, I.

PY - 2025/4/1

Y1 - 2025/4/1

N2 - This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.

AB - This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.

UR - https://www.scopus.com/pages/publications/105003688410

UR - https://www.mendeley.com/catalogue/6c43bdc2-7c0f-3276-a4b6-b2812e2cd4aa/

U2 - 10.1093/bjs/znaf061

DO - 10.1093/bjs/znaf061

M3 - Article

C2 - 40231433

AN - SCOPUS:105003688410

SN - 0007-1323

VL - 112

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 4

M1 - znaf061

ER -

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: Multicentre study from the Prospective Lynch Syndrome Database

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