Mesenchymal Stem Cells with Enhanced Therapeutic Properties

Mesenchymal stem cells with enhanced therapeutic properties. The present invention refers to a method for obtaining mesenchymal stem cells (MSCs) with enhanced immunosuppression, chondroprotection and chondrodifferentiation properties, and enhanced capability to promote the proliferation of chondrocytes. The method comprises contacting the MSCs; culturing MSC in a induction media supplemented with 0.01 to 100 µg/ml of an ATP-synthase inhibitor; and removing the induction media to obtain MSC with enhanced activity. Moreover, the present invention also refers to the MSCs themselves and to their use for cell therapy purposes, preferably for treating autoimmune and/or osteoarticular diseases.