Mathematical modeling for pharmacokinetic predictions from controlled drug release nano systems: A comparative parametric study

Ziyad S. Haidar*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the ÷2 minimization method, is employedconcluding that the Korsmeyer-Peppas modelprovides the best-ûtin all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.
Idioma originalInglés
Páginas (desde-hasta)1801-1806
Número de páginas6
PublicaciónBiomedical and Pharmacology Journal
Volumen11
N.º4
DOI
EstadoPublicada - dic. 2018

Nota bibliográfica

Publisher Copyright:
© 2018 Oriental Scientific Publishing Company.

Palabras clave

  • Drug dissolution
  • Least squares method
  • Mathematical modelling
  • Model comparison
  • Release kinetics
  • Statistical analysis

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