Resumen
Objective: sFLT-1 e15a is a recently described sFlt-1 variant that is placental and primate specific. As such, it may have potential as a biomarker. Using a newly developed ELISA, we measured maternal plasma sFLT-1 e15a levels in women with fetal growth restriction and pre-eclampsia. Method: We performed a nested case-control study where we measured total sFLT-1 and sFLT-1 e15a plasma protein concentrations. Samples, selected from a prospective cohort study, consisted of 87 healthy controls, 11 cases that developed term preeclampsia and 20 cases where there was fetal growth restriction. We also measured sFLT-1 and sFLT-1 e15a plasma concentrations in a separate cohort: 15 cases of preterm preeclampsia and 24 healthy controls. Results: The prospective case-control cohort demonstrated significantly increased sFLT-1 e15a among cases with term fetal growth restriction (p < 0.05). We also observed that total sFLT-1 (this ELISA indiscriminately detects all variants) was significantly increased in term preeclampsia (p < 0.0001), but not fetal growth restriction. The separate cohort of early-onset preeclamptics showed significantly increased sFLT-1 e15a levels (p < 0.0001). Conclusion: Plasma sFLT-1 e15a is significantly increased in early-onset preeclampsia and term fetal growth restriction. Further assessment of the benefit for sFLT-1 e15a testing in prediction or diagnosis of these disease states is warranted.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 635-639 |
Número de páginas | 5 |
Publicación | Journal of Maternal-Fetal and Neonatal Medicine |
Volumen | 30 |
N.º | 6 |
DOI | |
Estado | Publicada - 19 mar. 2017 |
Nota bibliográfica
Publisher Copyright:© 2016 Informa UK Limited, trading as Taylor & Francis Group.
Palabras clave
- Anti-angiogenic
- pre-eclampsia
- pregnancy
- sFLT-1 variant
- Small for gestational age