Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes

Pablo R. Olmos*, Attilio Rigotti, Dolores Busso, Loni Berkowitz, José L. Santos, Gisella R. Borzone, José A. Poblete, Claudio Vera, Cristián Belmar, Denisse Goldenberg, Bárbara Samith, Ana M. Acosta, Manuel Escalona, Ian Niklitschek, Jorge R. Mandiola, Nicolás Mertens

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

47 Citas (Scopus)

Resumen

Objective: Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels. Methods: Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI: normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD. Results: In the three groups respectively: LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN= 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN= 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively: r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001). Conclusions: In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.
Idioma originalInglés
Páginas (desde-hasta)2156-2163
Número de páginas8
PublicaciónObesity
Volumen22
N.º10
DOI
EstadoPublicada - 1 oct. 2014
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2014 The Obesity Society. 2014.

Palabras clave

  • Adult
  • Body Weight
  • Diabetes
  • Gestational
  • Female
  • Fetal Macrosomia
  • Gestational Age
  • Humans
  • Hypertriglyceridemia
  • Infant
  • Newborn
  • Obesity
  • Pregnancy
  • Pregnancy Complications
  • Prospective Studies

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