It’s time to measure what matters in inflammatory bowel disease

Core Outcome Sets (COS) provide standardized outcomes for randomized controlled trials (RCTs), enhancing consistency and comparability in research. In inflammatory bowel disease (IBD), the CORE-IBD Collaborators developed the first COS for RCTs, while the European Crohn’s and Colitis Organisation (ECCO) later introduced a COS for real-world data, addressing key domains such as disease activity, patient-reported outcomes, and healthcare utilization. Emerging imaging techniques are also shaping IBD research, likely influencing future COS development. Integrating COS into studies can improve evidence synthesis and foster a more standardized, patient-centered approach in IBD research and care.