Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses

Horacio Figueroa, Mauricio Lozano, Cristian Suazo, Elisenda Eixarch, Sebastián Illanes, Juan Eduardo Carreño, Sandra Villanueva, Edgar Hernández-Andrade, Eduard Gratacós, Carlos Ernesto Irarrazabal Muñoz*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

15 Citas (Scopus)

Resumen

The aim of this work was to study the effect of intrauterine growth restriction (IUGR) on fetal kidneys. The IUGR was induced by uteroplacental vessels ligature in a model of pregnant rabbit. We centralized the study in the gene expression of essential proteins for fetal kidney development and kidney protection against hypoxia, osmotic stress, and kidney injury. The gene expression of HIF-1α, NFAT5, IL-1β, NGAL, and ATM were studied by qRT-PCR and Western blot in kidneys from control and IUGR fetuses. Experimental IUGR fetuses were significantly smaller than the control animals (39 vs. 48 g, p < 0.05). The number of glomeruli was decreased in IUGR kidneys, without morphological alterations. IUGR increased the gene expression of HIF-1α, NFAT5, IL-1β, NGAL, and ATM (p < 0.05) in kidneys of fetuses undergoing IUGR, suggesting that fetal blood flow restriction produce alterations in gene expression in fetal kidneys.
Idioma originalInglés
Páginas (desde-hasta)899-904
Número de páginas6
PublicaciónEarly Human Development
Volumen88
N.º11
DOI
EstadoPublicada - nov. 2012

Huella

Profundice en los temas de investigación de 'Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses'. En conjunto forman una huella única.

Citar esto