Inmunoexpresión de E-cadherina y vimentina en mucosa oral normal, displasia epitelial oral y carcinoma oral de células escamosas

Natalia Santibáñez; Alejandra Fernández; Javier Fernández; René Martínez; Juan Pablo Fawaz; Sergio Olate; Ziyad S. Haidar

doi:10.4067/S0717-95022017000200035

Inmunoexpresión de E-cadherina y vimentina en mucosa oral normal, displasia epitelial oral y carcinoma oral de células escamosas

Título traducido de la contribución: Immunoexpression of E-cadherin and vimentin in normal oral mucosa, oral epithelial displasia and oral squamous cell carcinoma

Natalia Santibáñez, Alejandra Fernández, Javier Fernández, René Martínez, Juan Pablo Fawaz, Sergio Olate, Ziyad S. Haidar^*

^*Autor correspondiente de este trabajo

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3 Citas (Scopus)

Resumen

El objetivo fue evaluar la inmunoexpresión de E-cadherina y Vimentina en mucosa oral normal (MON), displasia epitelial oral (DEO) y carcinoma oral de células escamosas (COCE). Se realizó un estudio descriptivo de una serie de casos analizandolos mediante técnica de inmunohistoquímica contra E-cadherina y Vimentina 16 muestras de MON, 16 de DEO y 19 de COCE. La inmunotinción fue evaluada cualitativamente considerando extensión e intensidad para E-cadherina e intensidad para Vimentina. El análisis de la extensión e intensidad de la inmunotinción de E-cadherina y Vimentina según diagnóstico reveló una asociación estadísticamente significativa (p<0,001). Siendo la expresión de E-cadherina más alta en MON, seguido por DEO y más baja en COCE, inversamente a lo que se observó con Vimentina. El presente estudio reveló la subregulación del marcador molecular E-cadherina junto con la expresión aberrante por parte de células epiteliales del marcador mesenquimal Vimentina en muestras de MON, DEO y COCE.

Título traducido de la contribución	Immunoexpression of E-cadherin and vimentin in normal oral mucosa, oral epithelial displasia and oral squamous cell carcinoma
Idioma original	Español
Páginas (desde-hasta)	596-602
Número de páginas	7
Publicación	International Journal of Morphology
Volumen	35
N.º	2
DOI	https://doi.org/10.4067/S0717-95022017000200035
Estado	Publicada - jun. 2017

Nota bibliográfica

Publisher Copyright:
© 2017, Universidad de la Frontera. All rights reserved.

Palabras clave

Neoplasias orales
Transición epitelio-mesénquima
Cadherinas
Vimentina
Inmunohistoquímica

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10.4067/S0717-95022017000200035

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@article{8b596936ee2043d4a1495a92198b1769,

title = "Inmunoexpresi{\'o}n de E-cadherina y vimentina en mucosa oral normal, displasia epitelial oral y carcinoma oral de c{\'e}lulas escamosas",

abstract = "The aim was to evaluate the expression of E-cadherin and Vimentin in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), in comparison with normal oral mucosa (NOM) in a descriptive case study using immunohistochemistry. A total of fifty-one (N=51) histological samples were included; as follows: n = 16 (NOM), n = 16 (OED) and n = 19 (OSCC). All samples were analyzed using immunohistochemistry against the expression of E-cadherin and Vimentin. Immunostaining was qualitatively evaluated by extent and intensity of its expression for E-cadherin and intensity for Vimentin. Extension and intensity analysis of E-cadherin and Vimentin immunostaining according to group revealed a statistically significant association (r<0.001). E-cadherin expression was found to be highest in NOM followed by OED and lowest in OSCC, inverse to what was observed with Vimentin. The present study revealed the down regulation of the molecular marker Ecadherin, suggestive of reduction in dysplastic cells on comparison to NOM cells, and aberrant expression of the mesenchymal marker Vimentin by epithelial cells in samples of NOM, OED and OSCC; questioning their value as a prognostic marker.",

keywords = "Neoplasias orales, Transici{\'o}n epitelio-mes{\'e}nquima, Cadherinas, Vimentina, Inmunohistoqu{\'i}mica, Oral neoplasms, Epithelial mesenchymal transition, Cadherins, Vimentin, Immunohistochemistry",

author = "Natalia Santib{\'a}{\~n}ez and Alejandra Fern{\'a}ndez and Javier Fern{\'a}ndez and Ren{\'e} Mart{\'i}nez and Fawaz, {Juan Pablo} and Sergio Olate and Haidar, {Ziyad S.}",

year = "2017",

month = jun,

doi = "10.4067/S0717-95022017000200035",

language = "Spanish",

volume = "35",

pages = "596--602",

journal = "International Journal of Morphology",

issn = "0717-9367",

publisher = "Universidad de la Frontera",

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Inmunoexpresión de E-cadherina y vimentina en mucosa oral normal, displasia epitelial oral y carcinoma oral de células escamosas. / Santibáñez, Natalia; Fernández, Alejandra; Fernández, Javier et al.
En: International Journal of Morphology, Vol. 35, N.º 2, 06.2017, p. 596-602.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Inmunoexpresión de E-cadherina y vimentina en mucosa oral normal, displasia epitelial oral y carcinoma oral de células escamosas

AU - Santibáñez, Natalia

AU - Fernández, Alejandra

AU - Fernández, Javier

AU - Martínez, René

AU - Fawaz, Juan Pablo

AU - Olate, Sergio

AU - Haidar, Ziyad S.

PY - 2017/6

Y1 - 2017/6

N2 - The aim was to evaluate the expression of E-cadherin and Vimentin in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), in comparison with normal oral mucosa (NOM) in a descriptive case study using immunohistochemistry. A total of fifty-one (N=51) histological samples were included; as follows: n = 16 (NOM), n = 16 (OED) and n = 19 (OSCC). All samples were analyzed using immunohistochemistry against the expression of E-cadherin and Vimentin. Immunostaining was qualitatively evaluated by extent and intensity of its expression for E-cadherin and intensity for Vimentin. Extension and intensity analysis of E-cadherin and Vimentin immunostaining according to group revealed a statistically significant association (r<0.001). E-cadherin expression was found to be highest in NOM followed by OED and lowest in OSCC, inverse to what was observed with Vimentin. The present study revealed the down regulation of the molecular marker Ecadherin, suggestive of reduction in dysplastic cells on comparison to NOM cells, and aberrant expression of the mesenchymal marker Vimentin by epithelial cells in samples of NOM, OED and OSCC; questioning their value as a prognostic marker.

AB - The aim was to evaluate the expression of E-cadherin and Vimentin in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC), in comparison with normal oral mucosa (NOM) in a descriptive case study using immunohistochemistry. A total of fifty-one (N=51) histological samples were included; as follows: n = 16 (NOM), n = 16 (OED) and n = 19 (OSCC). All samples were analyzed using immunohistochemistry against the expression of E-cadherin and Vimentin. Immunostaining was qualitatively evaluated by extent and intensity of its expression for E-cadherin and intensity for Vimentin. Extension and intensity analysis of E-cadherin and Vimentin immunostaining according to group revealed a statistically significant association (r<0.001). E-cadherin expression was found to be highest in NOM followed by OED and lowest in OSCC, inverse to what was observed with Vimentin. The present study revealed the down regulation of the molecular marker Ecadherin, suggestive of reduction in dysplastic cells on comparison to NOM cells, and aberrant expression of the mesenchymal marker Vimentin by epithelial cells in samples of NOM, OED and OSCC; questioning their value as a prognostic marker.

KW - Neoplasias orales

KW - Transición epitelio-mesénquima

KW - Cadherinas

KW - Vimentina

KW - Inmunohistoquímica

KW - Oral neoplasms

KW - Epithelial mesenchymal transition

KW - Cadherins

KW - Vimentin

KW - Immunohistochemistry

UR - http://www.scopus.com/inward/record.url?scp=85021371055&partnerID=8YFLogxK

U2 - 10.4067/S0717-95022017000200035

DO - 10.4067/S0717-95022017000200035

M3 - Article

AN - SCOPUS:85021371055

SN - 0717-9367

VL - 35

SP - 596

EP - 602

JO - International Journal of Morphology

JF - International Journal of Morphology

IS - 2

ER -

Inmunoexpresión de E-cadherina y vimentina en mucosa oral normal, displasia epitelial oral y carcinoma oral de células escamosas

Resumen

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Palabras clave

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