Cancer cells increase their metabolic activity by enhancing glucose uptake through overexpression of hexose transporters (Gluts). Gluts also have the capacity to transport other molecules besides glucose, including fructose, mannose, and dehydroascorbic acid (DHA), the oxidized form of vitamin C. The majority of research studies in this field have focused on the role of glucose transport and metabolism in cancer, leaving a substantial gap in our knowledge of the contribution of other hexoses and DHA in cancer biology. Here, we summarize the most recent advances in understanding the role that the multifunctional transport capacity of Gluts plays in biological and clinical aspects of cancer, and how these characteristics can be exploited in the search for novel diagnostic and therapeutic strategies.
Nota bibliográficaFunding Information:
This review article was supported by the Department of Defense ( W81XWH-12-1-0341 ) to A.G., PhD Fellowship Universidad de los Andes , Chile to C.E., Fondecyt 1181243 to F.N., and PIA-Conicyt ECM-12 to F.N.
© 2021 Elsevier Ltd