Growth factor-assisted distraction osteogenesis and histiogenesis

Bone is one of the “organs” with the most spontaneous regenerative capabilities in the human body. Principally, a dynamic connective tissue formed as a direct result of the self assembly and mineralization of the extracellular matrix produced primarily by bone-forming cells or osteoblasts, in a remarkable orchestra-like interaction with two other cell types (at least to-date); osteocytes and osteoclasts maintaining and resorbing bone, respectively.