@article{c5c8cfa7dcf841919c1705c13e52210b,
title = "Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations",
abstract = "Genome-wide association studies (GWASs) have focused primarily on populations of European descent, but it is essential that diverse populations become better represented. Increasing diversity among study participants will advance our understanding of genetic architecture in all populations and ensure that genetic research is broadly applicable. To facilitate and promote research in multi-ancestry and admixed cohorts, we outline key methodological considerations and highlight opportunities, challenges, solutions, and areas in need of development. Despite the perception that analyzing genetic data from diverse populations is difficult, it is scientifically and ethically imperative, and there is an expanding analytical toolbox to do it well.",
keywords = "GWAS, admixed populations, ancestry, complex disease, cross-ancestry, diversity, population genetics, psychiatry, trans-ancestry, trans-ethnic, admixed populations, ancestry, complex disease, cross-ancestry, diversity, GWAS, population genetics, psychiatry, trans-ancestry, trans-ethnic",
author = "Peterson, {Roseann E.} and Karoline Kuchenbaecker and Walters, {Raymond K.} and Chen, {Chia Yen} and Popejoy, {Alice B.} and Sathish Periyasamy and Max Lam and Conrad Iyegbe and Strawbridge, {Rona J.} and Leslie Brick and Carey, {Caitlin E.} and Martin, {Alicia R.} and Meyers, {Jacquelyn L.} and Jinni Su and Junfang Chen and Edwards, {Alexis C.} and Allan Kalungi and Nastassja Koen and Lerato Majara and Emanuel Schwarz and Smoller, {Jordan W.} and Stahl, {Eli A.} and Sullivan, {Patrick F.} and Evangelos Vassos and Bryan Mowry and Prieto, {Miguel L.} and Alfredo Cuellar-Barboza and Bigdeli, {Tim B.} and Edenberg, {Howard J.} and Hailiang Huang and Duncan, {Laramie E.}",
note = "Funding Information: The authors acknowlesdge the support and helpful discussions with many members in the Psychiatric Genomics Consortium (PGC), which is supported by the National Institutes of Health (NIH) grants U01 MH109528, MH109539, MH109539, MH109536, MH109501, MH109514, MH109499, and MH109532. R.E.P. is supported by NIH grant K01 MH113848. K.K. is supported by Wellcome Trust grant 212360/Z/18/Z. R.K.W. is supported by the Stanley Center for Psychiatric Research and the National Institutes of Health (5U01MH109539). A.B.P. is supported by a postdoctoral fellowship from the Stanford Center for Computational, Evolutionary, and Human Genomics (CEHG). C.I. is supported by the NARSAD Young Investigator Award grant 22604. R.J.S. is supported by a UKRI Innovation-HDR-UK Fellowship (MR/S003061/1). A.R.M. is supported by NIH grant K99MH117229. M.L.P. is supported in part by grant CONICYT FONDECYT 1181365 and grant CONICYT FONDEF ID1910116. H.H. is supported by NIH K01DK114379, R21AI139012, the Zhengxu & Ying He Foundation, and the Stanley Center for Psychiatric Research. L.D. was supported by UL1 TR001085 and the Stanford Department of Psychiatry and Behavioral Sciences. P.F.S. was supported by the Swedish Research Council (Vetenskapsr?det, award D0886501), the Horizon 2020 Program of the European Union (COSYN, RIA grant agreement number 610307), and US NIMH (U01 MH109528 and R01 MH077139). P.F. Sullivan reports the following potentially competing financial interests. Current: Lundbeck (advisory committee, grant recipient). Past three years: Pfizer (scientific advisory board). Funding Information: The authors acknowlesdge the support and helpful discussions with many members in the Psychiatric Genomics Consortium (PGC), which is supported by the National Institutes of Health (NIH) grants U01 MH109528 , MH109539 , MH109539 , MH109536 , MH109501 , MH109514 , MH109499 , and MH109532 . R.E.P. is supported by NIH grant K01 MH113848 . K.K. is supported by Wellcome Trust grant 212360/Z/18/Z . R.K.W. is supported by the Stanley Center for Psychiatric Research and the National Institutes of Health ( 5U01MH109539 ). A.B.P. is supported by a postdoctoral fellowship from the Stanford Center for Computational, Evolutionary, and Human Genomics (CEHG). C.I. is supported by the NARSAD Young Investigator Award grant 22604 . R.J.S. is supported by a UKRI Innovation-HDR-UK Fellowship ( MR/S003061/1 ). A.R.M. is supported by NIH grant K99MH117229 . M.L.P. is supported in part by grant CONICYT FONDECYT 1181365 and grant CONICYT FONDEF ID1910116 . H.H. is supported by NIH K01DK114379 , R21AI139012 , the Zhengxu & Ying He Foundation , and the Stanley Center for Psychiatric Research . L.D. was supported by UL1 TR001085 and the Stanford Department of Psychiatry and Behavioral Sciences . P.F.S. was supported by the Swedish Research Council (Vetenskapsr{\aa}det, award D0886501 ), the Horizon 2020 Program of the European Union (COSYN, RIA grant agreement number 610307 ), and US NIMH ( U01 MH109528 and R01 MH077139 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "17",
doi = "10.1016/j.cell.2019.08.051",
language = "English",
volume = "179",
pages = "589--603",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "3",
}