Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population

J. Cuenca, C. A. Pérez, A. J. Aguirre, I. Schiattino, J. C. Aguillón

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

38 Citas (Scopus)

Resumen

Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position -308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illness. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases.
Idioma originalInglés estadounidense
Páginas (desde-hasta)237-241
Número de páginas5
PublicaciónBiological Research
Volumen34
N.º3-4
DOI
EstadoPublicada - 1 ene 2001
Publicado de forma externa

Huella Profundice en los temas de investigación de 'Genetic polymorphism at position -308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population'. En conjunto forman una huella única.

Citar esto