Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Francisco Bustos; Anna Segarra-Fas; Gino Nardocci; Andrew Cassidy; Odetta Antico; Lindsay Davidson; Lennart Brandenburg; Thomas J. Macartney; Rachel Toth; C. James Hastie; Jennifer Moran; Robert Gourlay; Joby Varghese; Renata F. Soares; Martin Montecino; Greg M. Findlay

doi:10.1016/j.devcel.2020.09.025

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Francisco Bustos
, Anna Segarra-Fas
, Gino Nardocci
, Andrew Cassidy
, Odetta Antico
, Lindsay Davidson
, Lennart Brandenburg
, Thomas J. Macartney
, Rachel Toth
, C. James Hastie
, Jennifer Moran
, Robert Gourlay
, Joby Varghese
, Renata F. Soares
, Martin Montecino
, Greg M. Findlay^*

^*Autor correspondiente de este trabajo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

37 Citas (Scopus)

Resumen

Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

Idioma original	Inglés
Páginas (desde-hasta)	629-647.e7
Publicación	Developmental Cell
Volumen	55
N.º	5
DOI	https://doi.org/10.1016/j.devcel.2020.09.025
Estado	Publicada - 7 dic. 2020
Publicado de forma externa	Sí

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© 2020 The Authors

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Bustos, F., Segarra-Fas, A., Nardocci, G., Cassidy, A., Antico, O., Davidson, L., Brandenburg, L., Macartney, T. J., Toth, R., Hastie, C. J., Moran, J., Gourlay, R., Varghese, J., Soares, R. F., Montecino, M., & Findlay, G. M. (2020). Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Developmental Cell, 55(5), 629-647.e7. https://doi.org/10.1016/j.devcel.2020.09.025

@article{016b59d78bc847b3be274308d7ef9fcb,

title = "Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling",

abstract = "Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.",

keywords = "development, metazoan evolution, neural development, neurodevelopmental disorders, protein kinase, protein phosphorylation, signal transduction, stem cells, transcriptomics, ubiquitin signaling",

author = "Francisco Bustos and Anna Segarra-Fas and Gino Nardocci and Andrew Cassidy and Odetta Antico and Lindsay Davidson and Lennart Brandenburg and Macartney, \{Thomas J.\} and Rachel Toth and Hastie, \{C. James\} and Jennifer Moran and Robert Gourlay and Joby Varghese and Soares, \{Renata F.\} and Martin Montecino and Findlay, \{Greg M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = dec,

day = "7",

doi = "10.1016/j.devcel.2020.09.025",

language = "English",

volume = "55",

pages = "629--647.e7",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "5",

}

Bustos, F, Segarra-Fas, A, Nardocci, G, Cassidy, A, Antico, O, Davidson, L, Brandenburg, L, Macartney, TJ, Toth, R, Hastie, CJ, Moran, J, Gourlay, R, Varghese, J, Soares, RF, Montecino, M & Findlay, GM 2020, 'Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling', Developmental Cell, vol. 55, n.º 5, pp. 629-647.e7. https://doi.org/10.1016/j.devcel.2020.09.025

TY - JOUR

T1 - Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

AU - Bustos, Francisco

AU - Segarra-Fas, Anna

AU - Nardocci, Gino

AU - Cassidy, Andrew

AU - Antico, Odetta

AU - Davidson, Lindsay

AU - Brandenburg, Lennart

AU - Macartney, Thomas J.

AU - Toth, Rachel

AU - Hastie, C. James

AU - Moran, Jennifer

AU - Gourlay, Robert

AU - Varghese, Joby

AU - Soares, Renata F.

AU - Montecino, Martin

AU - Findlay, Greg M.

PY - 2020/12/7

Y1 - 2020/12/7

N2 - Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

AB - Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

KW - development

KW - metazoan evolution

KW - neural development

KW - neurodevelopmental disorders

KW - protein kinase

KW - protein phosphorylation

KW - signal transduction

KW - stem cells

KW - transcriptomics

KW - ubiquitin signaling

UR - https://www.scopus.com/pages/publications/85095412691

U2 - 10.1016/j.devcel.2020.09.025

DO - 10.1016/j.devcel.2020.09.025

M3 - Article

C2 - 33080171

AN - SCOPUS:85095412691

SN - 1534-5807

VL - 55

SP - 629-647.e7

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

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