@article{016b59d78bc847b3be274308d7ef9fcb,
title = "Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling",
abstract = "Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.",
keywords = "development, metazoan evolution, neural development, neurodevelopmental disorders, protein kinase, protein phosphorylation, signal transduction, stem cells, transcriptomics, ubiquitin signaling",
author = "Francisco Bustos and Anna Segarra-Fas and Gino Nardocci and Andrew Cassidy and Odetta Antico and Lindsay Davidson and Lennart Brandenburg and Macartney, {Thomas J.} and Rachel Toth and Hastie, {C. James} and Jennifer Moran and Robert Gourlay and Joby Varghese and Soares, {Renata F.} and Martin Montecino and Findlay, {Greg M.}",
note = "Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = dec,
day = "7",
doi = "10.1016/j.devcel.2020.09.025",
language = "English",
volume = "55",
pages = "629--647.e7",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",
}