Fecal microbiota transplantation through colonoscopy in the treatment of recurrent Clostridioides difficile: Experience at a university center

Título traducido de la contribución: Trasplante de microbiota fecal mediante colonoscopia en el tratamiento de la infección por Clostridioides difficile recurrente: Experiencia de un Centro Universitario

R. Quera*, P. Nuñez, C. von Muhlenbrock, R. Espinoza

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Introduction: The majority of cases of Clostridioides difficile infection (CDI) respond to antibiotic treatment. Fecal microbiota transplantation (FMT) has been accepted as an effective treatment in cases of recurrent CDI. Aim: Our aim was to describe the clinical results of FMT performed for the treatment of recurrent CDI. Material and methods: The study was conducted on patients with recurrent CDI treated with FMT through colonoscopy, within the time frame of January 2021 and December 2023. Demographic and clinical data were collected, including pre-FMT treatment data, the FMT success rate, and clinical progression during follow-up. Telephone surveys were carried out to evaluate satisfaction. Results: Thirteen patients with a mean age of 55 years underwent FMT (including 7 patients above 65 years of age and one pregnant woman). Patients presented with a median of 3 previous episodes of CDI (range 2-4). The median time interval from first episode of CDI to FMT was 4 months (range 3-10). The effectiveness of a single FMT session was 100%. During post-FMT follow-up (median of 11 months, range 3-32), 3 patients have presented with a new CDI episode, and a successful second FMT was performed on 2 of them. No adverse events were registered, and all patients had a positive perception of FMT. Conclusions: In the present study, despite its small size, FMT through colonoscopy was shown to be a safe, effective, and lasting therapy in cases of recurrent CDI, concurring with results from larger studies.

Título traducido de la contribuciónTrasplante de microbiota fecal mediante colonoscopia en el tratamiento de la infección por Clostridioides difficile recurrente: Experiencia de un Centro Universitario
Idioma originalInglés
PublicaciónRevista de Gastroenterologia de Mexico
DOI
EstadoAceptada/en prensa - 2024

Nota bibliográfica

Publisher Copyright:
© 2024 Asociación Mexicana de Gastroenterología

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